公开(公告)号：EP1546086A2

公开(公告)日：2005-06-29

申请号：EP03761807.1

申请日：2003-06-25

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： HATTORI, K.,c/o Fujisawa Pharmaceutical Co., Ltd. ,  TOMISHITA, Yasuyo ,  IMANISHI, M.,c/o Fujisawa Pharmaceutical Co., Ltd

IPC分类号： C07C229/00

CPC分类号： C07D295/135 ,  C07C215/52 ,  C07C217/60 ,  C07C217/92 ,  C07C229/36 ,  C07C229/38 ,  C07C255/58 ,  C07C271/22 ,  C07C323/32 ,  C07C323/63 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/38 ,  C07D295/155 ,  Y02P20/55

摘要： The present invention relates to a compound formula [I]: Y is bond, -0-(CH2)n- (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R1 is hydrogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, R3 is hydrogen or lower alkyl, R4 is hydrogen or lower alkyl,R5 and R8 are each independently hydrogen, halogen, hydroxy,lower alkyl, etc., R6 is hydrogen, lower alkyl, etc., R9 is hydrogen or lower alkyl, and i is 1 or 2,or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.

摘要翻译： 本发明涉及化合物式[I]：其中，X为键，-CH 2 - 等，Y为键，-O-（CH 2）n - （其中n为1,2,3或 4）等，Z是氰基，四唑基等，R 1是氢，低级烷基等，R 2是氢或氨基保护基，R 3是氢或低级烷基，R 4是氢或低级烷基，R 5和 R8各自独立地为氢，卤素，羟基，低级烷基等，R6为氢，低级烷基等，R9为氢或低级烷基，i为1或2，或其盐。 本发明的化合物[I]及其药学上可接受的盐可用于预防和/或治疗疟原虫或尿失禁。