公开(公告)号：EP1292564A2

公开(公告)日：2003-03-19

申请号：EP01906332.0

申请日：2001-02-26

申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

发明人： TANIGUCHI, K.,c/o Fujisawa Pharmaceutical Co. Ltd ,  KAYAKIRI, H.,c/o Fujisawa Pharmaceutical Co. Ltd ,  SAKURAI, M.,c/o Fujisawa Pharmaceutical Co. Ltd. ,  FUJII, Naoakic/o Fujisawa Pharmaceutical Co. Ltd. ,  WASHIZUKA, K.,c/o Fujisawa Pharmaceutical Co. Ltd ,  HAMASHIMA, H.,c/o Fujisawa Pharmaceutical Co. Ltd ,  TOMISHIMA, Y.,c/oFujisawa Pharmaceutical Co. Ltd ,  HAMADA, K.,c/oFujisawa Pharmaceutical Co. Ltd ,  YAMAMOTO, N.,c/o Fujisawa Pharmaceutical Co. Ltd ,  ISHIKAWA, H.,c/o Fujisawa Pharmaceutical Co. Ltd ,  UNAMI, N.c/o Fujisawa Pharmaceutical Co. Ltd. ,  MIURA, T.,c/o Fujisawa Pharmaceutical Co. Ltd.

IPC分类号： C07C217/86 ,  A61K31/133 ,  A61P11/04 ,  C07C217/30 ,  C07D471/04 ,  C07C311/18 ,  C07C217/70

CPC分类号： C07D209/08 ,  C07C217/32 ,  C07C217/34 ,  C07C217/70 ,  C07C217/86 ,  C07C225/16 ,  C07C229/34 ,  C07C229/38 ,  C07C237/30 ,  C07C271/28 ,  C07C311/08 ,  C07C311/21 ,  C07D209/88 ,  C07D213/65 ,  Y02P20/55

摘要： A compound of the formula (I) wherein X1 is bond or -O(CH2)m- (in which m is an integral number of 1, 2 or 3); X2 is bond, -(CH2)n-, etc. (in which n is an integral number of 1, 2 or 3); R1 is hydrogen or amino protective group; R2 is hydroxy(lower)alkyl or (lower)alkoxy(lower)alkyl; A is phenyl, pyridyl, indolyl or carbazolyl, each of which may be substituted with one or two substituent(s) selected from the group consisting of halogen, hydroxy, lower alkyl, etc.; and B is phenyl or pyridyl, each of which may be substituted with one or two substituent(s) selected from the group consisting of halogen, hydroxy, nitro, etc.; and a pharmaceutically acceptable salt thereof which is useful as a medicament.

摘要翻译： 其中X1是键或-O（CH2）m-（其中m是1,2或3的整数）的式（I）化合物; X2是键， - （CH2）n-等（其中n是1,2或3的整数）。 R1是氢或氨基保护基; R2是羟基（低级）烷基或（低级）烷氧基（低级）烷基; A是苯基，吡啶基，吲哚基或咔唑基，它们各自可以被一个或两个选自卤素，羟基，低级烷基等的取代基取代; 和B是苯基或吡啶基，其中的每一个可以被一个或两个选自卤素，羟基，硝基等的取代基取代; 及其药学上可接受的盐，其可用作药物。