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    THIAZINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL CONMPOSITION COMPRISING THE SAME
    3.
    发明公开
    THIAZINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL CONMPOSITION COMPRISING THE SAME 失效
    噻嗪衍生物，其制备方法和包括其的药物反应

    公开(公告)号：EP0138223A3

    公开(公告)日：1986-12-30

    申请号：EP84112454

    申请日：1984-10-16

    申请人： FUJISAWA PHARMACEUTICAL CO., LTD.

    发明人： UEDA, IKUO ,  KATO, MASAYUKI FUJISAWA PHARMACEUTICAL CO., LTD. ,  KASAI, YOSHIHARU

    IPC分类号： C07D513/04 ,  A61K31/54

    CPC分类号： C07D513/04

    摘要： New thiazine derivatives of the formula: wherein R¹ is hydrogen or acyl,
    R² is hydrogen or lower alkyl,
    R³ is hydrogen, hydroxy, halogen, lower alkyl or lower alkoxy,
    Z is taken together with the adjacent carbon atoms to form an unsaturated heterocyclic ring which may be substituted with phenyl, halogen, acyl or lower alkyl, and the heavy solid line means single or double bond, and pharmaceutically accept­ able salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.
    These derivatives and salts thereof are useful as antiin­ flammatory, analgesic and antirheumatic agents.

    摘要翻译： 下式的新的噻嗪衍生物：其中R 1是氢或酰基，R 2是氢或低级烷基，R 3是氢，羟基，卤素，低级烷基或低级烷氧基，Z与相邻碳原子一起形成 可被苯基，卤素，酰基或低级烷基取代的不饱和杂环，重实线表示单键或双键，及其药学上可接受的盐，及其制备方法和包含其的药物组合物。 这些衍生物和其盐可用作抗炎，镇痛和抗风湿剂。