公开(公告)号：EP2872487B1

公开(公告)日：2017-04-26

申请号：EP13740184.0

申请日：2013-07-15

申请人： Fibrogen, Inc.

发明人： THOMPSON, Michael D. ,  PARK, Jung Min ,  AREND, Michael P.

IPC分类号： C07D217/26

CPC分类号： C07D217/26

公开(公告)号：EP2951159A1

公开(公告)日：2015-12-09

申请号：EP14704030.7

申请日：2014-01-23

申请人： Fibrogen, Inc.

发明人： WITSCHI, Claudia ,  THOMPSON, Michael D. ,  PARK, Jung Min ,  AREND, Michael P.

IPC分类号： C07D217/26 ,  A61K31/472 ,  A61P7/06

CPC分类号： C07D217/26

摘要： The present disclosure relates to crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid (Compound A), the process of preparing crystalline forms of Compound A, the pharmaceutical compositions containing them, and the methods of use thereof.

公开(公告)号：EP3470397A1

公开(公告)日：2019-04-17

申请号：EP18189607.7

申请日：2013-07-15

申请人： Fibrogen, Inc.

发明人： WITSCHI, Claudia ,  PARK, Jung Min ,  THOMPSON, Michael, D. ,  MARTINELLI, Michael, John ,  YEOWELL, David, A. ,  AREND, Michael, P.

IPC分类号： C07D217/26

摘要： The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof.

公开(公告)号：EP2872488B1

公开(公告)日：2018-08-22

申请号：EP13740185.7

申请日：2013-07-15

申请人： Fibrogen, Inc.

发明人： WITSCHI, Claudia ,  PARK, Jung Min ,  THOMPSON, Michael, D. ,  MARTINELLI, Michael, John ,  YEOWELL, David, A. ,  AREND, Michael, P.

IPC分类号： C07D217/26 ,  A61K31/47

CPC分类号： C07D217/26 ,  A61K31/47 ,  C07B2200/13

摘要： The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof.

公开(公告)号：EP3219706A1

公开(公告)日：2017-09-20

申请号：EP17155678.0

申请日：2013-07-15

申请人： Fibrogen, Inc.

发明人： THOMPSON, Michael D. ,  PARK, Jung Min ,  AREND, Michael P.

IPC分类号： C07D217/26

CPC分类号： C07D217/26

摘要： The present invention relates to methods for making isoquinoline compounds and the intermediate compounds achieved thereby. Such compounds can be used to prepare compounds and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).

公开(公告)号：EP2872487A1

公开(公告)日：2015-05-20

申请号：EP13740184.0

申请日：2013-07-15

申请人： Fibrogen, Inc.

发明人： THOMPSON, Michael D. ,  PARK, Jung Min ,  AREND, Michael P.

IPC分类号： C07D217/26

CPC分类号： C07D217/26

摘要： The present invention relates to methods for making isoquinoline compounds and the intermediate compounds achieved thereby. Such compounds can be used to prepare compounds and compositions capable of decreasing HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).

公开(公告)号：EP2872488A2

公开(公告)日：2015-05-20

申请号：EP13740185.7

申请日：2013-07-15

申请人： Fibrogen, Inc.

发明人： WITSCHI, Claudia ,  PARK, Jung Min ,  THOMPSON, Michael, D. ,  MARTINELLI, Michael, John ,  YEOWELL, David, A. ,  AREND, Michael, P.

IPC分类号： C07D217/26

CPC分类号： C07D217/26 ,  A61K31/47 ,  C07B2200/13

摘要： The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof.

摘要翻译： 本公开涉及[（4-羟基-1-甲基-7-苯氧基 - 异喹啉-3-羰基） - 氨基] - 乙酸的结晶固体形式，制备所述形式的方法，以及药物组合物和使用方法 它们。

公开(公告)号：EP4029854A1

公开(公告)日：2022-07-20

申请号：EP21212372.3

申请日：2013-07-15

申请人： Fibrogen, Inc.

发明人： WITSCHI, Claudia ,  PARK, Jung Min ,  THOMPSON, Michael D. ,  MARTINELLI, Michael John ,  YEOWELL, David A. ,  AREND, Michael P.

IPC分类号： C07D217/26

摘要： The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof.

公开(公告)号：EP2951159B1

公开(公告)日：2018-08-22

申请号：EP14704030.7

申请日：2014-01-23

申请人： Fibrogen, Inc.

发明人： WITSCHI, Claudia ,  THOMPSON, Michael D. ,  PARK, Jung Min ,  AREND, Michael P.

IPC分类号： C07D217/26 ,  A61K31/472 ,  A61P7/06

CPC分类号： C07D217/26

摘要： The present disclosure relates to crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid (Compound A), the process of preparing crystalline forms of Compound A, the pharmaceutical compositions containing them, and the methods of use thereof.