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公开(公告)号：EP2324834B1
公开(公告)日：2019-05-08
申请号：EP10181843.3
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： Klaus, Stephen J. , Lin, Al Y. , Neff, Thomas B. , Wang, Qingjian , Guenzler-Pukall, Volkmar , Arend, Michael P. , Flippin, Lee A.
IPC分类号： A61K31/47 , A61K31/4738 , A61K31/63 , A61K31/00 , A61K38/38 , C12N15/09 , C12Q1/56 , C12Q1/34 , A61P7/06 , A61K31/17 , C07K14/47 , C07K14/505 , G01N33/74 , A61K31/472 , A61K31/4745 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/496 , A61K38/17
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公开(公告)号：EP2295059A3
公开(公告)日：2013-04-03
申请号：EP10180933.3
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： Guenzler-Pukall, Volkmar , Neff, Thomas B. , Wang, Qingjian , Flippin, Lee A. , Arend, Michael P.
IPC分类号： A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/17 , A61K31/00 , C07K14/47 , C07K14/505 , A61P7/06 , A61P9/10 , G01N33/74 , C12N15/09 , C12Q1/34 , C12Q1/56
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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3.发明公开CTGF as target for the therapy of diabetic nephropathy 审中-公开糖尿病患者的CTGF抑制剂zur Behandlung von Proteinurie
公开(公告)号：EP1977762A1
公开(公告)日：2008-10-08
申请号：EP08011905.0
申请日：2005-02-11
申请人： FIBROGEN, INC.
发明人： Flyvbjerg, Allan , Guo, Guangjie , Liu, David Y. , Neff, Thomas B. , Oliver, Noelynn A. , Usinger, William R. , Wang, Qingjian
IPC分类号： A61K39/39 , A61K39/395 , A61K31/00 , A61K38/00 , A61P13/12
CPC分类号： A61K38/556 , A61K31/00 , A61K39/395 , A61K2039/505 , C07K16/22 , A61K2300/00
摘要： The present invention relates to methods and compounds for treating specific early stage aspects and late stage aspects of diabetic nephropathy. Methods and compounds for treating various physiological features associated with early stage and with late stage diabetic nephropathy are also provided.
摘要翻译： 本发明涉及用于治疗糖尿病肾病的特异性早期方面和晚期方面的方法和化合物。 还提供了用于治疗与早期和晚期糖尿病肾病相关的各种生理特征的方法和化合物。
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公开(公告)号：EP2295060B1
公开(公告)日：2018-10-31
申请号：EP10181210.5
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： Guenzler-Pukall, Volkmar , Neff, Thomas B. , Wang, Qingjian , Flippin, Lee A. , Arend, Michael P.
IPC分类号： A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/17 , A61K31/00 , C07K14/47 , C07K14/505 , A61P7/06 , A61P9/10 , G01N33/74 , C12N15/09 , C12Q1/34 , C12Q1/56
CPC分类号： A61K31/00 , A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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公开(公告)号：EP2289531A3
公开(公告)日：2013-03-13
申请号：EP10181768.2
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： Klaus, Stephen J. , Lin, Al Y. , Neff, Thomas B. , Wang, Qingjian , Guenzler-Pukall, Volkmar , Arend, Michael P. , Flippin, Lee A.
IPC分类号： A61K38/00 , C12N15/09 , C12Q1/56 , C12Q1/34 , A61K31/00 , A61K31/47 , A61K31/4738 , A61K31/63 , A61P7/06 , A61K38/17 , C07K14/47 , C07K14/505 , G01N33/74
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to compounds for use in methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo . Compounds for use in methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included.
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公开(公告)号：EP2338914A1
公开(公告)日：2011-06-29
申请号：EP10184854.7
申请日：2004-06-02
申请人： Fibrogen, Inc.
发明人： Lin, Ai Y. , Neff, Thomas B. , Oliver, Noelynn A. , Usinger, William R. , Wang, Qingjian , Yeowell, David A.
IPC分类号： C07K16/22 , A61K39/395 , A61P27/06 , A61P35/04 , C12N5/12
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/41 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies that bind to CTGF. The antibodies are particularly directed to regions of CTGF involved in biological activities associated with fibrosis. The invention also relates to methods of using the antibodies to treat disorders associated with CTGF including localized and systemic fibrotic disorders including those of the lung, liver, heart, skin, and kidney.
摘要翻译： 本发明涉及结合CTGF的抗体。 抗体特别针对参与与纤维化相关的生物活性的CTGF的区域。 本发明还涉及使用抗体治疗与CTGF相关的疾病的方法，包括局部和全身纤维化疾病，包括肺，肝脏，心脏，皮肤和肾脏的疾病。
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公开(公告)号：EP2289531A2
公开(公告)日：2011-03-02
申请号：EP10181768.2
申请日：2002-12-06
申请人： FIBROGEN, INC.
发明人： Klaus, Stephen J. , Lin, Al Y. , Neff, Thomas B. , Wang, Qingjian , Guenzler-Pukall, Volkmar , Arend, Michael P. , Flippin, Lee A.
IPC分类号： A61K38/00 , C12N15/09 , C12Q1/56 , C12Q1/34 , A61K31/00 , A61K31/47 , A61K31/4738 , A61K31/63 , A61P7/06
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to compounds for use in methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo . Compounds for use in methods for treating, pretreating or preconditioning, or preventing erythropoietin-associated conditions are also included.
摘要翻译： 本发明涉及用于通过在体外和体内增加内源促红细胞生成素来治疗促红细胞生成素相关病症的方法中使用的化合物。 还包括用于治疗，预处理或预处理或预防促红细胞生成素相关病症的方法的化合物。
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公开(公告)号：EP2289531B1
公开(公告)日：2018-07-04
申请号：EP10181768.2
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： Klaus, Stephen J. , Lin, Al Y. , Neff, Thomas B. , Wang, Qingjian , Guenzler-Pukall, Volkmar , Arend, Michael P. , Flippin, Lee A.
IPC分类号： A61K38/00 , C12N15/09 , C12Q1/56 , C12Q1/34 , A61K31/00 , A61K31/47 , A61K31/4738 , A61K31/63 , A61P7/06 , A61K38/17 , C07K14/47 , C07K14/505 , G01N33/74 , A61K31/472 , A61K31/4745 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/496
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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公开(公告)号：EP2295060A3
公开(公告)日：2013-03-13
申请号：EP10181210.5
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： Guenzler-Pukall, Volkmar , Neff, Thomas B. , Wang, Qingjian , Flippin, Lee A. , Arend, Michael P.
IPC分类号： A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/17 , A61K31/00 , C07K14/47 , C07K14/505 , A61P7/06 , A61P9/10 , G01N33/74 , C12N15/09 , C12Q1/34 , C12Q1/56
CPC分类号： A61K31/00 , A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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公开(公告)号：EP2324834A3
公开(公告)日：2013-02-13
申请号：EP10181843.3
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： Klaus, Stephen J. , Lin, Al Y. , Neff, Thomas B. , Wang, Qingjian , Guenzler-Pukall, Volkmar , Arend, Michael P. , Flippin, Lee A.
IPC分类号： A61K31/47 , A61K31/4738 , A61K31/63 , A61K31/00 , A61K38/38 , C12N15/09 , C12Q1/56 , C12Q1/34 , A61P7/06 , A61K38/17 , C07K14/47 , C07K14/505 , G01N33/74
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in vitro and in vivo . Compounds for treating, pretreating or preconditioning, or preventing neurological disorders are also included.
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