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公开(公告)号：EP1890721B1
公开(公告)日：2010-09-22
申请号：EP06733813.7
申请日：2006-01-25
CPC分类号： A61K9/0019 , A61K38/1808 , A61K38/1825 , A61K38/1858 , A61K38/1866 , A61K38/2006 , A61K38/2093 , A61K38/212 , A61K38/2285 , A61K38/2292 , A61K38/30 , A61K2300/00
摘要： Pharmaceutical polypeptide compositions promote the survival of cardiac cells, recruit cardiac cells to the cardiac area, stimulate the differentiation of cardiac cells, stimulate the proliferation of cardiac cells, and promote the activity of cardiac cells, thereby treating cardiac conditions. Methods of providing these compositions to the cardiac area include catheterization and direct injection. In preferred embodiements, the compositions comprise one of more of the following growth factors: EGF, bFGF, cardiotrophin-1, thrombin, PDGF-BB, amphiregulin, epiregulin, HB-EGF, TGFalpha, betacellulin, heregulin alpha, NRG-1-betal-HRG-betal, FGF 9.
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公开(公告)号：EP1890721A2
公开(公告)日：2008-02-27
申请号：EP06733813.7
申请日：2006-01-25
CPC分类号： A61K9/0019 , A61K38/1808 , A61K38/1825 , A61K38/1858 , A61K38/1866 , A61K38/2006 , A61K38/2093 , A61K38/212 , A61K38/2285 , A61K38/2292 , A61K38/30 , A61K2300/00
摘要： Pharmaceutical polypeptide compositions promote the survival of cardiac cells, recruit cardiac cells to the cardiac area, stimulate the differentiation of cardiac cells, stimulate the proliferation of cardiac cells, and promote the activity of cardiac cells, thereby treating cardiac conditions. Methods of providing these compositions to the cardiac area include catheterization and direct injection. In preferred embodiements, the compositions comprise one of more of the following growth factors: EGF, bFGF, cardiotrophin-1, thrombin, PDGF-BB, amphiregulin, epiregulin, HB-EGF, TGFalpha, betacellulin, heregulin alpha, NRG-1-betal-HRG-betal, FGF 9.
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