公开(公告)号：EP1596813A2

公开(公告)日：2005-11-23

申请号：EP04775751.3

申请日：2004-01-30

申请人： Five Prime Therapeutics, Inc.

发明人： HESTIR, Kevin ,  LEE, Ernestine ,  CHU, Keting ,  WANG, Yan ,  PIERCE, Kristen ,  COLLINS, Amy L., Tsui ,  WILLIAMS, Lewis, Thomas

IPC分类号： A61K6/00

CPC分类号： G01N33/57423 ,  C07K16/40 ,  G01N33/574 ,  G01N2333/70596

摘要： Modulators of phosphatidic acid phosphatase type 2C and other polypeptides, highly expressed in cancers as compared to normal tissues, are provided for treatment of proliferative disorders such as cancer. A method is provided for detecting polypeptides that are overexpressed in cancer, whereby antibodies or binding proteins that specifically recognize these molecules are contacted with a patient's bodily fluid. The method provides an early diagnosis of cancer, and can detect recurrence and metastasis following an initial diagnosis. The invention further provides methods of treating cancer with therapeutic agents directed toward these protein and peptide biomarkers.