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公开(公告)号：EP3019606B1
公开(公告)日：2018-09-05
申请号：EP14823682.1
申请日：2014-07-11
CPC分类号： C12N13/00 , B06B1/0238 , B06B1/0648 , B06B2201/76 , C07K1/145 , C12M47/02 , C12P21/02
摘要： A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.
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公开(公告)号：EP2825279B1
公开(公告)日：2020-05-27
申请号：EP13760840.2
申请日：2013-03-15
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公开(公告)号：EP3341463A1
公开(公告)日：2018-07-04
申请号：EP16725630.4
申请日：2016-04-26
发明人： LIPKENS, Bart , MILLER, Erik , ROSS-JOHNSRUD, Benjamin , PRESZ, JR., Walter M. , CHITALE, Kedar , KENNEDY, III, Thomas J. , WINIARSKI, Lauryn
CPC分类号： C12M29/10 , B01D21/283 , C12M33/00 , C12M47/02 , C12M47/10
摘要： Acoustic perfusion devices for separating biological cells from other material in a fluid mixture are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid mixture is being drawn.
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公开(公告)号：EP2903715B1
公开(公告)日：2020-07-22
申请号：EP13844181.1
申请日：2013-09-13
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5.发明公开
公开(公告)号：EP2825279A1
公开(公告)日：2015-01-21
申请号：EP13760840.2
申请日：2013-03-15
IPC分类号： B01D43/00
CPC分类号： B01D43/00 , B06B1/0644 , C12M47/02
摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
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公开(公告)号：EP3500659A1
公开(公告)日：2019-06-26
申请号：EP16754152.3
申请日：2016-08-16
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公开(公告)号：EP3092049A1
公开(公告)日：2016-11-16
申请号：EP15700941.6
申请日：2015-01-08
发明人： LIPKENS, Bart , MCCARTHY, Brian , ROSS-JOHNSRUD, Ben , BARNES, Jason , MEALEY, Dane , KENNEDY, III, Thomas J.
IPC分类号： B01D21/28
CPC分类号： C12N13/00 , B01D21/283
摘要： An acoustophoresis device includes an acoustic chamber with a piezoelectric element located within its volume. The piezoelectric element vibrates and generates acoustic standing waves from both sides, so that particles can be separated from fluid passing through the acoustic chamber. This permits the element to be cooled more efficiently, reducing transient heat loads in the fluid traveling through the device.
摘要翻译： 一种声电泳装置包括具有位于其体积内的压电元件（160）的声室（155,157）。 压电元件振动并从两侧产生声驻波，使得颗粒可以与通过声室的流体分离。 这允许元件更有效地冷却，减少流过装置的流体中的瞬时热负荷。
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公开(公告)号：EP3019606A1
公开(公告)日：2016-05-18
申请号：EP14823682.1
申请日：2014-07-11
CPC分类号： C12N13/00 , B06B1/0238 , B06B1/0648 , B06B2201/76 , C07K1/145 , C12M47/02 , C12P21/02
摘要： A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.
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9.发明公开ACOUSTOPHORETIC SEPARATION TECHNOLOGY USING MULTI-DIMENSIONAL STANDING WAVES 审中-公开对于多维AKUSTOPHORETISCHE驻波分离技术
公开(公告)号：EP2903715A2
公开(公告)日：2015-08-12
申请号：EP13844181.1
申请日：2013-09-13
CPC分类号： B06B1/06 , B06B2201/70 , C12M47/02
摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
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