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1.发明授权DUAL INHIBITOR COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS AND ALZHEIMER'S DISEASE 有权双重抑制剂化合物用于治疗神经退行性疾病和阿尔茨海默病
公开(公告)号：EP3154953B1
公开(公告)日：2018-04-04
申请号：EP15731721.5
申请日：2015-06-12
发明人： CAVALLI, Andrea , PRATI, Federica , BOTTEGONI, Giovanni , FAVIA, Angelo Danilo , PIZZIRANI, Daniela , SCARPELLI, Rita , BOLOGNESI, Maria Laura
IPC分类号： C07D251/10 , A61K31/53
CPC分类号： C07D251/10 , A61K31/53 , A61K45/06 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/12
摘要： The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the prevention or treatment of central nervous system diseases or disorders, in particular, cognitive, neurodegenerative or neuronal diseases or disorders.
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2.发明公开DUAL INHIBITOR COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISORDERS AND ALZHEIMER'S DISEASE 有权双重抑制剂化合物，其用在神经退行性故障的处理和阿尔茨海默氏病
公开(公告)号：EP3154953A1
公开(公告)日：2017-04-19
申请号：EP15731721.5
申请日：2015-06-12
发明人： CAVALLI, Andrea , PRATI, Federica , BOTTEGONI, Giovanni , FAVIA, Angelo Danilo , PIZZIRANI, Daniela , SCARPELLI, Rita , BOLOGNESI, Maria Laura
IPC分类号： C07D251/10 , A61K31/53
CPC分类号： C07D251/10 , A61K31/53 , A61K45/06 , C07D401/04 , C07D401/12 , C07D403/12 , C07D409/12
摘要： The present invention relates to Compounds of Formula (I) and pharmaceutical compositions containing the same. It further relates to their use in the prevention or treatment of central nervous system diseases or disorders, in particular, cognitive, neurodegenerative or neuronal diseases or disorders.
摘要翻译： 本发明涉及药物组合物包含相同的式（I）的化合物和。 本发明还涉及它们在预防或治疗中枢神经系统疾病或障碍，特别是认知，神经变性或神经元疾病或病症的用途。
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3.发明授权PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR) 有权苯基氨基甲酸酯及其作为D3多巴明受体（D3DR）的脂肪酸酰胺水解酶（FAAH）酶和调节剂的抑制剂的用途
公开(公告)号：EP3022179B1
公开(公告)日：2017-11-15
申请号：EP14744009.3
申请日：2014-07-10
发明人： BOTTEGONI, Giovanni , DE SIMONE, Alessio , RUDA, Gian Filippo , CAVALLI, Andrea , BANDIERA, Tiziano , PIOMELLI, Daniele
IPC分类号： C07D209/88 , C07D211/38 , C07D213/30 , C07D295/125 , C07D295/13 , A61K31/495 , A61K31/496 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/30 , C07D211/14
CPC分类号： C07D295/13 , C07D209/88 , C07D211/14 , C07D211/38 , C07D213/30 , C07D295/125
摘要： The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar′, R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MTDLs) that are at the same time inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR), their methods of preparation, formulations and therapeutic applications thereof.
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4.发明授权
公开(公告)号：EP3055293B1
公开(公告)日：2017-12-06
申请号：EP14781590.6
申请日：2014-10-09
发明人： GRIMALDI, Benedetto , TORRENTE, Esther , SCARPELLI, Rita , BOTTEGONI, Giovanni , BANDIERA, Tiziano , VERONESI, Marina
IPC分类号： C07D309/14 , C07D211/06 , C07D295/04 , C07D295/185 , C07D487/08 , C07D333/08 , C07D241/38 , C07D471/08 , A61K31/445 , A61K31/495 , A61P35/00
CPC分类号： A61K31/496 , A61K31/445 , A61K31/4453 , A61K31/495 , C07D211/06 , C07D211/58 , C07D241/38 , C07D295/04 , C07D295/08 , C07D295/16 , C07D295/185 , C07D309/14 , C07D333/08 , C07D333/20 , C07D471/08 , C07D487/08
摘要： The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and pro-apoptotic agents for cancer therapy.
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公开(公告)号：EP3055293A1
公开(公告)日：2016-08-17
申请号：EP14781590.6
申请日：2014-10-09
发明人： GRIMALDI, Benedetto , TORRENTE, Esther , SCARPELLI, Rita , BOTTEGONI, Giovanni , BANDIERA, Tiziano , VERONESI, Marina
IPC分类号： C07D309/14 , C07D211/06 , C07D295/04 , C07D295/185 , C07D487/08 , C07D333/08 , C07D241/38 , C07D471/08 , A61K31/445 , A61K31/495 , A61P35/00
CPC分类号： A61K31/496 , A61K31/445 , A61K31/4453 , A61K31/495 , C07D211/06 , C07D211/58 , C07D241/38 , C07D295/04 , C07D295/08 , C07D295/16 , C07D295/185 , C07D309/14 , C07D333/08 , C07D333/20 , C07D471/08 , C07D487/08
摘要： The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and pro-apoptotic agents for cancer therapy.
摘要翻译： 其进一步公开了一种药物组合物，其包含式（I）化合物及其用作癌症治疗的抗增殖和促凋亡剂。
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6.发明公开PHENYL CARBAMATES AND THEIR USE AS INHIBITORS OF THE FATTY ACID AMIDE HYDROLASE (FAAH) ENZYME AND MODULATORS OF THE D3 DOPAMINE RECEPTOR (D3DR) 有权苯基氨基甲酸酯以及它们作为脂肪酸酰胺水解酶抑制剂（FAAH）酶和多巴胺D 3受体的调节剂（D3DR）
公开(公告)号：EP3022179A1
公开(公告)日：2016-05-25
申请号：EP14744009.3
申请日：2014-07-10
发明人： BOTTEGONI, Giovanni , DE SIMONE, Alessio , RUDA, Gian Filippo , CAVALLI, Andrea , BANDIERA, Tiziano , PIOMELLI, Daniele
IPC分类号： C07D209/88 , C07D211/38 , C07D213/30 , C07D295/125 , C07D295/13 , A61K31/495 , A61K31/496 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/30
CPC分类号： C07D295/13 , C07D209/88 , C07D211/14 , C07D211/38 , C07D213/30 , C07D295/125
摘要： The invention provides compounds of Formula (I) or pharmaceutically acceptable salts thereof wherein Ar′, R1, R2, R3, R4, X, Y are as defined in the description of invention, as multi-target directed ligands (MTDLs) that are at the same time inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR), their methods of preparation, formulations and therapeutic applications thereof.
摘要翻译： 本发明提供了式（I）的化合物或其药学上可接受的盐其中Ar”，R1，R2，R3，R4，X，Y是如本发明的描述限定，并且多目标定向配体（MTDLs）并处于 脂肪酸酰胺水解酶的抑制剂的Sametime（FAAH）的酶和多巴胺D 3受体（D3DR）它们的制备，配方和灰以及它们的治疗应用的方法的调节剂。
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