公开(公告)号：EP3483164B1

公开(公告)日：2020-03-04

申请号：EP18209919.2

申请日：2018-03-20

申请人： Forma Therapeutics, Inc.

发明人： ERICSSON, Anna ,  GREEN, Neal ,  GUSTAFSON, Gary ,  HAN, Bingsong ,  LANCIA JR., David, R ,  MITCHELL, Lorna ,  RICHARD, David ,  SHELEKHIN, Tatiana ,  SMITH, Chase C. ,  WANG, Zhongguo ,  ZHENG, Xiaozhang

IPC分类号： C07D487/04 ,  A61K31/407 ,  C07D519/00 ,  A61P7/00

公开(公告)号：EP3680241A1

公开(公告)日：2020-07-15

申请号：EP20158204.6

申请日：2018-03-20

申请人： Forma Therapeutics, Inc.

发明人： ERICSSON, Anna ,  GREEN, Neal ,  GUSTAFSON, Gary ,  HAN, Bingsong ,  LANCIA JR., David, R ,  MITCHELL, Lorna ,  RICHARD, David ,  SHELEKHIN, Tatiana ,  SMITH, Chase C. ,  WANG, Zhongguo ,  ZHENG, Xiaozhang

IPC分类号： C07D487/04 ,  A61K31/407 ,  C07D519/00 ,  A61P7/00

摘要： The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.