公开(公告)号：EP3416669A1

公开(公告)日：2018-12-26

申请号：EP17708179.1

申请日：2017-02-16

申请人： Forschungszentrum Borstel Leibniz-Zentrum für Medizin und Biowissenschaften ,  Freie Universität Berlin ,  Universität zu Lübeck ,  Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen

发明人： BRANDENBURG, Klaus ,  HEINBOCKEL, Lena ,  REILING, Norbert ,  MARTINEZ DE TEJADA, Guillermo ,  SCHÜRHOLZ, Tobias ,  MAUSS, Karl ,  WEINDL, Günther

IPC分类号： A61K38/10 ,  C07K7/08 ,  C07K14/47

CPC分类号： C07K14/4723 ,  A61K38/00 ,  C07K7/08 ,  Y02A50/473

摘要： The present invention relates to a pharmaceutical composition comprising or consisting of a combination of (a) two or more peptides, each peptide consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the N-terminus, are as follows (1) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y, W or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) K or L or lacking; (11) W, L or F; (12) K or R; (13) F, Y or C; (14) K or R; (15) G or Q; (16) K or R; (17) F, L or W; (18) F or W; (19) F, L or W; (20) W or F; (21) C or lacking; (22) F or G or lacking; (23) G or lacking; or (b) one or more peptides, each peptide consisting of or comprising 17 to 23 amino acids, wherein the amino acids in positions 1 to 23, counted from the N-terminus, are as follows (1) G, S or lacking; (2) C or lacking; (3) K or R; (4) K or R; (5) Y, W or F; (6) K or R; (7) K or R; (8) F, W or L; (9) K or R; (10) K or L or lacking; (11 ) W, L or F; (12) K or R; (13) F, Y or C; (14) K or R; (15) G or Q; (16) K or R; (17) F, L or W; (18) F or W; (19) F, L or W; (20) W or F; (21) C or lacking; (22) F or G or lacking; (23) G or lacking, and one or more antibiotics selected from small organic molecule antibiotics such as ceftriaxone, oxacillin, amoxicillin, amikacin, ciprofloxacin, erythromycin, imipenem and tetracycline, and peptidic antibiotics such as daptomycin and vancomycin.