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公开(公告)号：EP1786927B1
公开(公告)日：2009-01-07
申请号：EP05774381.7
申请日：2005-08-12
发明人： POGHOSSIAN, Arshak , CHERSTVY, Andrey , SCHÖNING, Michael, Josef , INGEBRANDT, Sven , KEUSGEN, Michael
IPC分类号： C12Q1/68 , G01N27/333
CPC分类号： G01N27/3276 , G01N27/3335
摘要： The invention relates to a device for detecting charged macromolecules, comprising an ion-sensitive layer, on the surface of which a sample molecule is immobilized in order to detect a target molecule, the sample molecule and target molecules that are to be detected being able to create a specific bond. The inventive device is characterized in that the sample molecules are immobilized at a minimum distance from each other on the ion-sensitive layer such that a redistribution of the zone concentration is induced in the intermolecular interstices during bonding with the target molecule. Also disclosed is a method for detecting charged macromolecules with the aid of the inventive device.
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公开(公告)号：EP1786927A1
公开(公告)日：2007-05-23
申请号：EP05774381.7
申请日：2005-08-12
发明人： POGHOSSIAN, Arshak , CHERSTVY, Andrey , SCHÖNING, Michael, Josef , INGEBRANDT, Sven , KEUSGEN, Michael
IPC分类号： C12Q1/68 , G01N27/333
CPC分类号： G01N27/3276 , G01N27/3335
摘要： The invention relates to a device for detecting charged macromolecules, comprising an ion-sensitive layer, on the surface of which a sample molecule is immobilized in order to detect a target molecule, the sample molecule and target molecules that are to be detected being able to create a specific bond. The inventive device is characterized in that the sample molecules are immobilized at a minimum distance from each other on the ion-sensitive layer such that a redistribution of the zone concentration is induced in the intermolecular interstices during bonding with the target molecule. Also disclosed is a method for detecting charged macromolecules with the aid of the inventive device.
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