专利检索 ap:("Fraunhofer Gesellschaft zur Förderung der angewandten Forschung E.V." OR "Rheinisch-Westfälisch-Technische Hochschule Aachen") AND inv:"HEIN, Lea Christin" 第 1 页

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发明公开
ANTI-CD89 CYTOTOXIC COMPLEX 审中-公开
标题翻译：抗CD89细胞毒素复合物

公开(公告)号：EP3273991A1

公开(公告)日：2018-01-31

申请号：EP15713853.8

申请日：2015-03-25

申请人： Fraunhofer Gesellschaft zur Förderung der angewandten Forschung E.V. , Rheinisch-Westfälisch-Technische Hochschule Aachen

发明人： STEIN, Christoph , MLADENOV, Radoslav , STOCKMEYER, Bernhard , BARTH, Stefan , HEIN, Lea Christin , FISCHER, Rainer

IPC分类号： A61K39/395 , C07K16/28 , A61K47/48 , A61K39/00

CPC分类号： A61K39/395 , A61K47/6809 , A61K47/6849 , C07K16/28 , C07K2317/74 , G01N33/566 , G01N33/574

摘要： Complexes suitable for targeting and killing a human target cell comprising a first polypeptide with a binding structure for binding the complex to the cellular surface receptor CD89 (e.g. with an anti CD89 antibody) presented on the cell surface of the human target cell and a second polypeptide comprising a toxic effector domain, preferably Pseudomonas exotoxin A); to nucleic acid molecules encoding said complexes, vectors, host cells containing the nucleic acids and methods for preparation and producing such complexes; compositions and methods for using said complexes for the treatment of diseases, in particular of cancer diseases like leukemia.