公开(公告)号：EP3646852A1

公开(公告)日：2020-05-06

申请号：EP18203133.6

申请日：2018-10-29

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. ,  Martin-Luther-Universität Halle-Wittenberg

发明人： KIESOW, Andreas ,  BUCHHOLZ, Mirko ,  SAREMBE, Sandra ,  MÄDER, Karsten ,  KIRCHBERG, Martin ,  EICK, Sigrun

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K31/65 ,  C07C237/26 ,  A61P31/04

摘要： The present invention generally relates to controlled release of tetracycline antibiotics. Specifically, it relates to a complex comprising a tetracycline compound (TC) or a pharmaceutically acceptable salt, hydrate or solvate thereof and a divalent metal carboxylate; a pharmaceutical preparation comprising the complex, methods for manufacturing the complex and the pharmaceutical preparation, and a complex or a pharmaceutical preparation for use in a method for treatment of the human or animal body, in particular for therapy and/or prophylaxis of a bacterial infection; and/or wherein antibiotic activity is maintained over a prolonged period of time; and/or for the therapy and/or prophylaxis of an acute, chronic or recurrent periodontal disease.

公开(公告)号：EP3873432A1

公开(公告)日：2021-09-08

申请号：EP19804637.7

申请日：2019-10-29

申请人： FRAUNHOFER-GESELLSCHAFT zur Förderung der angewandten Forschung e.V.

发明人： KIESOW, Andreas ,  BUCHHOLZ, Mirko ,  SAREMBE, Sandra ,  MÄDER, Karsten ,  KIRCHBERG, Martin ,  EICK, Sigrun

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K31/65 ,  C07C237/26 ,  A61P31/04