公开(公告)号：EP3964497A1

公开(公告)日：2022-03-09

申请号：EP20194568.0

申请日：2020-09-04

申请人： Friedrich-Alexander-Universität Erlangen-Nürnberg

发明人： GMEINER, Peter ,  HUEBNER, Harald ,  HETZER, Florian

IPC分类号： C07C275/24 ,  C07C275/26 ,  C07D333/74 ,  A61P25/36 ,  A61K31/36

摘要： The present invention relates to a compound of the following formula (I) or (II), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, cocrystal, tautomer, racemate, enantiomer, or diastereomer or mixture thereof:

The invention furthermore relates to a pharmaceutical composition comprising the compound having formula (I) or (II) and optionally one or more pharmaceutically acceptable excipient(s) and/or carrier(s), as well as to these compounds for use in the treatment, amelioration or prevention of pain, opioid overdose, addictions, neuropsychiatric disorders, Prader-Willi Syndrome, gastrointestinal disorders, skin disorders, dyspnea, headache and/or temporomandibular joint dysfunction, including methods of treating, ameliorating or preventing pain involving administering to a patient in need thereof an effective amount of the compound having formula (I) or (II).