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    Method for detecting abnormal spots of nucleic acid microarray
    2.
    发明公开
    Method for detecting abnormal spots of nucleic acid microarray 有权
    福尔法罕zur Erkennung异常Punkte einesNukleinsäuremikroarrays

    公开(公告)号：EP2261370A1

    公开(公告)日：2010-12-15

    申请号：EP10164051.4

    申请日：2010-05-27

    申请人： Fujifilm Corporation ,  National University Corporation Tokyo Medical and Dental University

    发明人： Yoshida, Junya ,  Kanehara, Hideyuki ,  Ujihara, Dai ,  Inazawa, Johji ,  Imoto, Issei

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： G06F19/20 ,  C12Q1/6837 ,  C12Q2525/161 ,  C12Q2545/101

    摘要： A method carries out a nucleic acid analysis using a nucleic acid microarray. A probe nucleic acid including a probe sequence (a') complementary to a target sequence (a) and a sequence (b') which is different from the probe sequence (a') is immobilized on the nucleic acid microarray. The method includes hybridizing the nucleic acid microarray and a labeled abnormality detecting nucleic acid (B) containing a sequence (b) which can be bound to the sequence (b'), obtaining a labeled amount value (Fc1) of the labeled abnormality detecting nucleic acid (B) from a spot (X1), and determining, based on the measured labeled amount value (Fc1), as to whether or not the spot (X1) is an abnormal spot unsuitable for detecting the target nucleic acid.

    摘要翻译： 一种方法使用核酸微阵列进行核酸分析。 包含与靶序列（a）互补的探针序列（a'）和不同于探针序列（a'）的序列（b'）的探针核酸被固定在核酸微阵列上。 该方法包括将核酸微阵列和含有可与序列（b'）结合的序列（b）的标记异常检测核酸（B）杂交，得到标记的异常检测核酸的标记量值（Fc1） 根据测定的标记量值（Fc1），确定斑点（X1）是否是不适于检测靶核酸的异常斑点。

    FLUORESCENCE IMAGE ANALYSIS METHOD, FLUORESCENCE IMAGE ANALYSER, FLUORESENCE IMAGE ANALYSIS PROGRAM
    8.
    发明公开
    FLUORESCENCE IMAGE ANALYSIS METHOD, FLUORESCENCE IMAGE ANALYSER, FLUORESENCE IMAGE ANALYSIS PROGRAM 审中-公开

    公开(公告)号：EP4137795A1

    公开(公告)日：2023-02-22

    申请号：EP22190967.4

    申请日：2022-08-18

    申请人： National University Corporation Tokyo Medical and Dental University ,  Kyoto Prefectural Public University Corporation ,  SYSMEX CORPORATION

    发明人： Inazawa, Johji ,  Kuroda, Junya ,  Kinoshita, Masaki

    IPC分类号： G01N15/14 ,  G01N21/64 ,  G06T7/00 ,  G01N15/10

    摘要： A fluorescence image analyzer 10 has an imaging unit 154 for capturing a first image containing at least a part of a region of a cell as an imaging target for a plurality of cells in a sample in which a target site on a chromosome is labeled with a fluorescent dye, and a second image including fluorescence generated from a fluorescent dye labeling the target site of the cell of the first image. The processing unit 11 of the fluorescence image analyzer 10 selects a plurality of test cells having specific morphological characteristics to be tested from a plurality of cells based on at least the first image, and extracts the bright spots of fluorescence generated from the fluorescent dye from at least a plurality of test cells. The processing unit 11 identifies cells with chromosomal abnormalities and/or cells without chromosomal abnormalities based on the extracted bright spots, and generates information related to the ratio of cells with chromosomal abnormalities relative to the test cells based on the number of cells with chromosomal abnormalities and/or the number of cells without chromosomal abnormalities.

    Method for diagnosing cancer using cancer-associated deletion gene marker
    9.
    发明公开
    Method for diagnosing cancer using cancer-associated deletion gene marker 审中-公开
    Verfahren zur Krebsdiagnose mittels Genmarkerfürkrebsassoziierte Deletionen

    公开(公告)号：EP1852513A2

    公开(公告)日：2007-11-07

    申请号：EP07007420.8

    申请日：2007-04-11

    申请人： FUJIFILM Corporation ,  Tokyo Medical and Dental University

    发明人： Inazawa, Johji ,  Imoto, Issei ,  Izumi, Hiroyuki ,  Yokoi, Sana

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  G01N33/57423

    摘要： It is an object of the present invention to provide a novel method for diagnosing cancer by discovering a cancer-associated gene which could not be detected by a conventional technique, and detecting deletion, mutation, or an abnormal expression level of such cancer-associated gene. The present invention pmvides a method for diagnosing cancer which comprises a step of detecting deletion of the GMDS, ANKRD15, TEK, or EBI2 gene in a test sample by using DNA containing all or part of said gene.

    摘要翻译： 本发明的目的是提供一种通过发现通过常规技术无法检测到的癌症相关基因并检测这种癌症相关基因的缺失，突变或异常表达水平来诊断癌症的新方法 。 本发明提供了一种用于诊断癌症的方法，其包括通过使用含有全部或部分所述基因的DNA检测测试样品中GMDS，ANKRD15，TEK或EBI2基因的缺失的步骤。