公开(公告)号：EP3712128A1

公开(公告)日：2020-09-23

申请号：EP19382189.9

申请日：2019-03-18

申请人： Fundació Institut Català d'Investigació Química (ICIQ) ,  Institució Catalana de Recerca i Estudis Avançats (ICREA)

发明人： MUÑIZ KLEIN, Kilian ,  BOSNIDOU, Alexandra

IPC分类号： C07D207/34 ,  C07C303/40 ,  C07D209/88

摘要： Problem: The present invention solves the problem of providing an alternative metal-free method for intermolecular amination of C-H bonds applicable to a broad range of substrates, wherein the substrate is essentially in stoichiometric amounts with respect to the amination reagent.
Solution: The present invention relates to a photochemical method for the intermolecular coupling of an amination agent with a compound comprising a fragment of formula -C a -H, said method converting the fragment of formula - C a -H in a fragment of formula -C a -NSO 2 R 1 , and comprising the step of contacting under light irradiation and in an aprotic solvent an amination agent with a compound comprising a fragment of formula -C a -H in the presence of a compound of formula (I)

         Arl(O 2 CR 3 ) 2      (I)

and a catalytically effective amount of iodine wherein the amination agent is selected from the compounds of formula R 1 SO 2 NHR 2 and the compounds of formula R 1 SO 2 N=IR 2 '.