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公开(公告)号：EP3740196A1
公开(公告)日：2020-11-25
申请号：EP19700424.5
申请日：2019-01-15
申请人： Fundación Instituto de Investigación Sanitaria De Santiago de Compostela (FIDIS) , Servizo Galego de Saude
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公开(公告)号：EP3740755A1
公开(公告)日：2020-11-25
申请号：EP19700508.5
申请日：2019-01-15
发明人： DE LA FUENTE FREIRE, Maria , LÓPEZ LÓPEZ , Rafael , ALONSO NOCELO, Marta , VÁZQUEZ RÍOS, Abi Judit
IPC分类号： G01N33/574 , A61K31/00
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公开(公告)号：EP3510995A1
公开(公告)日：2019-07-17
申请号：EP18382012.5
申请日：2018-01-15
申请人： Fundación Para A Investigación, Desenvolvemento E Innovación Ramón Domínguez , Servizo Galego de Saude
发明人： DE LA FUENTE FREIRE, María , LÓPEZ LÓPEZ, Rafael , LÓPEZ BOUZO, Belén , VÁZQUEZ RÍOS, Abi Judit , ALONSO NOCELO, Marta
IPC分类号： A61K9/107 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/44 , A61K49/00 , A61K49/10 , A61K49/18
摘要： In the present invention, the development of various oil-in-water (O / W) nanoemulsions containing an oil phase or oil core, preferably selected from vitamin E or oleic acid, stabilized by a sphingolipid of the sphingomyelin type, and optionally other lipids such as phospholipids, cholesterol, octadecylamine, DOTAP (N- [1- (2,3-Dioleoyloxy) propyl] -N, N, N-trimethylammonium methyl-sulfate), and PEGylated derivatives (derivatives with polyethylene glycol), for use as a nanotech vehicle , in particular for the management of cancer and metastatic disease, is herein described. Said nanoemulsions can be functionalized with ligands capable of interacting or binding to receptors expressed on the cell membrane of tumor cells, and in particular capable of interacting or binding to receptors expressed on the membrane of primary and/or disseminated or metastatic tumor cells. Also, antitumor drugs or therapeutic biomolecules can be encapsulated in said nanoemulsions and, finally, contrast agents can be incorporated for their use in the in vivo diagnosis in said nanoemulsions.
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