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1.发明公开
公开(公告)号：EP3939999A1
公开(公告)日：2022-01-19
申请号：EP20382631.8
申请日：2020-07-14
申请人： Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) , Fundación Investigación Biomédica Hospital Universitario 12 de Octubre
发明人： OJEDA MÁRQUEZ, Laura , FERRER SÁNCHEZ, Irene , PAZ-ARES RODRÍGUEZ, Luis , MARTÍNEZ TORRECUADRADA, Jorge Luis , RONCADOR, Giovanna
摘要： The present invention relates to neutralizing antibodies which specifically recognize the interleukin 11 receptor alpha subunit (IL11RA) extracellular domain and to antibody drug conjugates (ADCs) comprising a therapeutic agent and said neutralizing antibodies. The invention also relates to a method for detecting the IL-11 receptor, to pharmaceutical compositions and to the use of said antibodies or ADCs in the treatment of diseases characterized by an increased IL11RA signaling.
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2.发明公开
公开(公告)号：EP4182345A1
公开(公告)日：2023-05-24
申请号：EP21743184.0
申请日：2021-07-14
申请人： Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) , Fundación Investigación Biomédica Hospital Universitario 12 de Octubre
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