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公开(公告)号：EP2131813B1
公开(公告)日：2012-08-08
申请号：EP08709428.0
申请日：2008-02-15
IPC分类号： A61K9/00
CPC分类号： A61K9/0014 , A61K9/08 , A61K31/196 , A61K47/10 , A61K47/14
摘要： A composition for topical application of an NSAID comprises a solution or suspension of the NSAID in a carrier system comprising a polyhydric alcohol, a glycol ether and an ester of A higher fatty acid, the carrier system being present as a single phase at ambient temperatures. The NSATD may be diclofenac as diclofenac acid. The polyhydric alcohol may be a glycol such as isopropylene glycol and the glycol ether may be a diethylene glycol ether such as diethylene glycol monoethyl ether.
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公开(公告)号：EP1978931A1
公开(公告)日：2008-10-15
申请号：EP07704988.0
申请日：2007-01-23
CPC分类号： A61K9/0014 , A61K9/0034 , A61K9/145 , A61K31/21 , A61K45/06 , A61K47/10 , A61K47/32 , A61K2300/00
摘要： A composition for topical application to a part of the body comprises a local anaesthetic and optionally a vasodilator as active ingredient dissolved in a blend of volatile and non-volatile solvents of different solvating capacities for the active ingredient. The vasodilator may comprise glyceryl trinitrate and the local anaesthetic may comprises an anaesthetic of the aminoamide or aminoester type. The volatile solvent may comprise a mixture of water with a C1-C5 alcohol and the non-volatile solvent may comprise a polyhydric alcohol and optionally a glycol. A low-concentration vasodilator-containing composition is also described. The compositions allow a “virtual injection” of the active ingredient to be delivered transdermally without general systemic uptake.
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公开(公告)号：EP2131813A2
公开(公告)日：2009-12-16
申请号：EP08709428.0
申请日：2008-02-15
IPC分类号： A61K9/00
CPC分类号： A61K9/0014 , A61K9/08 , A61K31/196 , A61K47/10 , A61K47/14
摘要： A composition for topical application of an NSAID comprises a solution or suspension of the NSAID in a carrier system comprising a polyhydric alcohol, a glycol ether and an ester of A higher fatty acid, the carrier system being present as a single phase at ambient temperatures. The NSATD may be diclofenac as diclofenac acid. The polyhydric alcohol may be a glycol such as isopropylene glycol and the glycol ether may be a diethylene glycol ether such as diethylene glycol monoethyl ether.
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