专利检索 ap:("G.D. SEARLE & CO.") AND inv:"CRICH, Joyce, Z." 第 1 页

1.

发明公开
1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS 审中-公开
标题翻译：取代1,5-二芳基吡唑AS p38激酶抑制剂

公开(公告)号：EP1077971A1

公开(公告)日：2001-02-28

申请号：EP99921363.0

申请日：1999-05-12

申请人： G.D. SEARLE & CO.

发明人： WEIER, Richard, M. , COLLINS, Paul, W. , XU, Xiangdong , CRICH, Joyce, Z. , RAO, Shashidhar, N.

IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , A61K31/44 , A61K31/505

CPC分类号： C07D401/04 , C07D401/14 , C07D403/04

摘要： The present invention contemplates 1,5-diaryl-substituted pyrazole compounds which correspond in structure to Formula (I), or a pharmaceutically-acceptable salt thereof: wherein A is =N- or =CH-; and which inter alia, inhibit the activity of p38 MAP kinase. Also contemplated by the invention are processes for the preparation of the contemplated compounds and for the use of a contemplated compound in treating a mammalian host having a p38 kinase- or TNF-mediated disease.