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    Substituted pyrimidoquinoxalines
    2.
    发明公开
    Substituted pyrimidoquinoxalines 失效
    取代基嘧啶基喹喔啉。

    公开(公告)号：EP0256545A1

    公开(公告)日：1988-02-24

    申请号：EP87111892.3

    申请日：1987-08-17

    申请人： G.D. Searle & Co.

    发明人： Ellames, George John ,  Lawson, Kevin Robert ,  Jaxa-Chamiec, Albert Andrej ,  Upton, Roger Munro

    IPC分类号： C07D487/04 ,  A61K31/505

    CPC分类号： C07D487/04

    摘要： This disclosure relates to a novel class of substituted quinoxaline derivatives of formula
    wherein
           R¹ and R² are independently hydrogen or alkyl;
           R³ and R⁴ are independently selected from the class consisting of hydrogen, halo, alkyl, and alkoxy;
           R⁵ is halo or trifluoromethyl;
    The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions as anti-anaerobic agents.

    摘要翻译： 本公开涉及新一类式CHEM的取代喹喔啉衍生物，其中R 1和R 2独立地是氢或烷基; R 3和R 4独立地选自氢，卤素，烷基和烷氧基; R 5为卤素或三氟甲基; 本公开还涉及含有这些化合物的药物组合物以及这些化合物和组合物作为抗厌氧剂的用途。

    Substituted dihydroimidazo[1,2-a]quinoxalines
    3.
    发明公开
    Substituted dihydroimidazo[1,2-a]quinoxalines 失效
    取代二氢咪唑并[1,2-a]喹喔啉。

    公开(公告)号：EP0214632A2

    公开(公告)日：1987-03-18

    申请号：EP86112322.2

    申请日：1986-09-05

    申请人： G.D. Searle & Co.

    发明人： Ellames, George John ,  Jaxa-Chamiec, Albert Andrej

    IPC分类号： C07D487/04 ,  C07D471/14 ,  A61K31/495

    CPC分类号： C07D471/14 ,  C07D487/04

    摘要： This invention relates to a novel class of substituted dihydroimidazo [1,2-α] quinoxaline derivatives of the formula
    wherein

    R' is C 1 -C 6 alkyl, benzyl, phenyl, a
    group, a
    group or a
    group wherein R 4 is C 1 -C 6 alkyl, and R 6 is C 1 -C 8 alkyl, ami- nome-
    thyl, pyridinyl, phenyl, halophenyl or a
    group wherein R 8 is C 1 -C 6 alkyl;
    R 2 is phenyl or substituted phenyl having 1 or 2 substituents selected from the class consisting of halo or C 1 -C 6 alkoxy;
    R 3 is hydrogen or halogen; and
    and to pharmaceutical compositions containing such compounds. The compounds and compositions are effective as anti-anaerobic agents.

    摘要翻译： 本发明涉及一类新的取代的二氢咪唑并[1,2-a]喹喔啉衍生物，其结构式为：其中R 1为C 1 -C 6烷基，苄基，苯基， ，......（NH 2 - @ -CH 2） - 基团或......（R 5 - ）） - 基团，其中R 4是C 1 -C 6烷基，R 5是C 1 -C 8烷基 ，氨基甲基，吡啶基，苯基，卤代苯基或......（R 6 -O-R 1 -NHCH 2） - 基团，其中R 6是C 1 -C 6烷基; R 2是苯基或具有1或 2个选自卤素或C 1 -C 6烷氧基的取代基; R 3是氢或卤素; 和X是-CH-或-N- ...以及含有这些化合物的药物组合物。 化合物和组合物作为抗厌氧剂是有效的。

    Substituted quinoxalines
    6.
    发明公开
    Substituted quinoxalines 失效
    取代基喹喔啉。

    公开(公告)号：EP0257508A1

    公开(公告)日：1988-03-02

    申请号：EP87111891.5

    申请日：1987-08-17

    申请人： G.D. Searle & Co.

    发明人： Ellames, George John ,  Jaxa-Chamiec, Albert Andrej ,  Myers, Peter Leslie ,  Upton, Roger Munro

    IPC分类号： C07D471/14 ,  C07D471/20 ,  A61K31/505

    CPC分类号： C07D471/14

    摘要： This disclosure relates to a novel class of substituted quinoxaline derivatives of the formula
    wherein
    R¹ and R² are independently selected from the class consisting of hydrogen, halo, alkyl, and alkoxy;
    R³ and R⁴ are independently hydrogen or alkyl or R³ and R⁴ together may be a
    group wherein n is an integer from 0 to 4; and
    X, Y and Z are independently -CH- or -N= provided that one and only one of X, Y or Z must be -N=.
    The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions as anti-anaerobic agents.

    摘要翻译： 本公开涉及新一类式CHEM的取代喹喔啉衍生物，其中R 1和R 2独立地选自氢，卤素，烷基和烷氧基; R 3和R 4独立地是氢或烷基或R 3和R 4一起可以是基团，其中n是0-4的整数; X，Y和Z独立地为-CH-或-N =，条件是X，Y或Z中的一个且仅一个必须为-N =。 本公开还涉及含有这些化合物的药物组合物以及这些化合物和组合物作为抗厌氧剂的用途。

    Substituted dihydroimidazo[1,2-a]quinoxalines
    7.
    发明公开
    Substituted dihydroimidazo[1,2-a]quinoxalines 失效
    取代二氢咪唑并[1,2-A]喹啉

    公开(公告)号：EP0214632A3

    公开(公告)日：1988-02-24

    申请号：EP86112322

    申请日：1986-09-05

    申请人： G.D. Searle & Co.

    发明人： Ellames, George John ,  Jaxa-Chamiec, Albert Andrej

    IPC分类号： C07D487/04 ,  C07D471/14 ,  A61K31/495 ,  C07D241/00 ,  C07D235/00 ,  C07D221/00

    CPC分类号： C07D471/14 ,  C07D487/04

    摘要： This invention relates to a novel class of substituted dihydroimidazo [1,2-α] quinoxaline derivatives of the formula
    wherein
    R' is C 1 -C 6 alkyl, benzyl, phenyl, a
    group, a
    group or a
    group wherein R 4 is C 1 -C 6 alkyl, and R 6 is C 1 -C 8 alkyl, ami- nome-
    thyl, pyridinyl, phenyl, halophenyl or a
    group wherein R 8 is C 1 -C 6 alkyl; R 2 is phenyl or substituted phenyl having 1 or 2 substituents selected from the class consisting of halo or C 1 -C 6 alkoxy; R 3 is hydrogen or halogen; and
    and to pharmaceutical compositions containing such compounds. The compounds and compositions are effective as anti-anaerobic agents.