公开(公告)号：EP1230219A1

公开(公告)日：2002-08-14

申请号：EP00913317.4

申请日：2000-02-22

申请人： G.D. Searle & Co.

发明人： Barta, Thomas E. ,  Becker, Daniel P. ,  Bedell, Louis J. ,  Boehm, Terri L. ,  Carroll, Jeffery N. ,  De Crescenzo, Gary A. ,  Fobian, Yvette M. ,  Freskos, John N. ,  Getman, Daniel P. ,  McDonald, Joseph J. ,  Hanson, Gunnar J. ,  Hockerman, Susan L. ,  Howard, Susan C. ,  Kolodziej, Steve A. ,  Li, Hui ,  Mischke, Deborah A. ,  Rico, Joseph G. ,  Stehle, Nathan W. ,  Tollerson, Michael B. ,  Vernier, William F. ,  Villamil, Clara I. ,  Rao, Shashidahar N.

IPC分类号： C07D211/66

CPC分类号： C07D451/02 ,  A61K31/445 ,  C07D207/16 ,  C07D211/66 ,  C07D211/78 ,  C07D221/22 ,  C07D221/24 ,  C07D225/02 ,  C07D239/04 ,  C07D239/10 ,  C07D239/14 ,  C07D239/22 ,  C07D263/06 ,  C07D265/30 ,  C07D277/06 ,  C07D279/06 ,  C07D281/06 ,  C07D285/16 ,  C07D307/24 ,  C07D309/08 ,  C07D319/06 ,  C07D327/02 ,  C07D333/38 ,  C07D335/02 ,  C07D337/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  Y02A50/411

摘要： A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9 and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. Also disclosed are metalloprotease inhibitor compounds having those selective activities, processes for manufacture of such compounds and pharmaceutical compositions using an inhibitor.