公开(公告)号：EP0668785A1

公开(公告)日：1995-08-30

申请号：EP92922383.0

申请日：1992-09-14

申请人： GAMBRO AB

发明人： JÖNSSON, Sven ,  KJELLSTRAND, Per ,  MARTINSON, Evi ,  WIESLANDER, Anders ,  SVENSSON, Eva ,  ANDREN, Anders

IPC分类号： A61J1 ,  A61J3 ,  A61K9 ,  A61K31 ,  A61M1 ,  A61P3

CPC分类号： A61M1/287 ,  Y10S206/828

摘要： System employing a sterile medical solution containing glucose or glucose-like compounds, for example nutritional solutions or solutions for peritoneal dialysis, whereby the majority of the solution is packed in a first package (A), whilst the glucose or the glucose-like compounds are separately packed in a second package (B), whereafter the two packages are heat sterilized. The invention is characterized in that the content of the glucose or glucose-like compounds in the second package (B) is maintained above 10 % by weight, suitable above 20 % by weight and preferably in the order of 40 % by weight in order to reduce or totally eliminate the breakdown of said compounds. The invention also relates to a solution intended for the system according to the invention. The solution is characterized in that, after sterilization, mixing and diluting to 1,5 % glucose content, it has an absorbency caused by breakdown products from glucose at 228 nm less than 0,35 and preferably in the order of 0,20 or lower. Alternatively, the solution according to the invention is defined in that, after sterilization, mixing and dilution to 1,5 % glucose content, it has an ICG-value caused by breakdown products from glucose less than 50 %, preferably less than 30 %.

公开(公告)号：EP1131108A1

公开(公告)日：2001-09-12

申请号：EP99970925.6

申请日：1999-10-20

申请人： GAMBRO AB

发明人： KJELLSTRAND, Per

IPC分类号： A61L2/04

CPC分类号： A61J1/2093 ,  A61J1/10 ,  A61J1/2027 ,  A61L2/04

摘要： A method and an apparatus (40) for reducing the degradation of heat sensitive components in medical substances during heat sterilisation are described. The medical substances are contained in a multiple chamber recipient (10, 60) that comprises a first chamber (12) with a first medical substance and at least one second chamber (14, 50) containing an amount of a second medical substance that is smaller than that of the first medical substance. The multiple chamber recipient (10, 60) is heated to a predetermined temperature for sterilising the medical substances, and the second chamber (14, 50) with the second medical substance is thermally insulated during heating of the multiple chamber recipient (10, 60). The multiple chamber recipient (10, 60) is held at this temperature for a predetermined time and is subsequently cooled. A predetermined time after commencing heating of the multiple chamber recipient (10, 60) the thermal insulation of the second chamber (14, 50) is removed, so that a defined hold time of the second chamber (14, 50) at the sterilisation temperature is obtained.