公开(公告)号：EP1843792A1

公开(公告)日：2007-10-17

申请号：EP05814407.2

申请日：2005-11-18

申请人： GE Healthcare AS ,  GE Healthcare Limited

发明人： WICKSTROM, Lill Torild, Amersham Health AS ,  VELD, Dirk in't, Amersham Health AS ,  OSBORN, Nigel John, GE Healthcare Limited ,  GRIGG, Julian, GE Healthcare Limited ,  WILSON, Anthony, GE Healthcare Limited

IPC分类号： A61K51/04 ,  C07H5/00

CPC分类号： C07H5/00 ,  C07H1/00 ,  C07H5/02 ,  C07H13/04

摘要： The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-beta-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.

公开(公告)号：EP1843792B1

公开(公告)日：2017-01-04

申请号：EP05814407.2

申请日：2005-11-18

申请人： GE HEALTHCARE AS ,  GE Healthcare Limited

发明人： WICKSTROM, Lill Torild, Amersham Health AS ,  VELD, Dirk in't, Amersham Health AS ,  OSBORN, Nigel John, GE Healthcare Limited ,  GRIGG, Julian, GE Healthcare Limited ,  WILSON, Anthony, GE Healthcare Limited

IPC分类号： A61K51/04 ,  C07H5/00

CPC分类号： C07H5/00 ,  C07H1/00 ,  C07H5/02 ,  C07H13/04

摘要： The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-beta-D-mannopyranose which are used as precursors for production of radiofluoridated sugar derivatives for use in in vivo imaging procedures such as positron emission tomography (PET). The method comprises storing the non fluoridated sugar derivative in an organic solvent. The resultant formulations of the non fluoridated sugar derivative and cassettes for automated synthesis apparatus comprising the same are also claimed.

摘要翻译： 本发明涉及一种提高非氟化糖衍生物，特别是诸如1,3,4,6-四-O-乙酰基-2-O-三氟甲磺酰基-β-D-吡喃甘露糖的葡萄糖衍生物的稳定性的方法，它们是 用作生产放射性氟化糖衍生物的前体，用于体内成像方法如正电子发射断层扫描（PET）。 该方法包括将非氟化糖衍生物储存在有机溶剂中。 还要求保护所得的非氟化糖衍生物的制剂和用于包含其的自动化合成装置的盒。