公开(公告)号：EP2576520A1

公开(公告)日：2013-04-10

申请号：EP11724884.9

申请日：2011-05-26

申请人： GE Healthcare Limited

发明人： NEWINGTON, Ian, Martin ,  WYNN, Duncan George ,  NAIRNE, Robert James Domett ,  GUILBERT, Benedicte ,  MANDAL, Subrata ,  JOSE, Jinto ,  VARADARAJAN, Sunderaraman ,  RANGASWAMY, Chitralekha ,  BETTS, Helen ,  DAVIS, Rebecca

IPC分类号： C07D251/30 ,  C07D251/52 ,  C07D263/58 ,  C07D277/74 ,  C07D277/82 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/496 ,  A61K51/04 ,  A61P25/00

CPC分类号： C07D401/04 ,  A61K51/0459 ,  A61K51/0461 ,  B01J19/00 ,  C07D209/14 ,  C07D211/96 ,  C07D213/74 ,  C07D213/75 ,  C07D217/06 ,  C07D233/88 ,  C07D239/88 ,  C07D249/04 ,  C07D253/075 ,  C07D263/46 ,  C07D263/58 ,  C07D277/36 ,  C07D277/64 ,  C07D277/74 ,  C07D295/096 ,  C07D295/125 ,  C07D327/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： The present invention relates to radiodiagnostic compounds, methods of making those compounds, and methods of use thereof as imaging agents for preferably a HA serotonin 5-HT1A receptor for use in PET or SPECT, preferably PET. Compositions comprising an imaging-effective amount of radiolabeled compounds are also disclosed. The present invention also relates to non-radiolabeled compounds, methods of making those compounds, and methods of use thereof to treat various neurological and/or psychiatric disorders.