公开(公告)号：EP3590933A1

公开(公告)日：2020-01-08

申请号：EP19184916.5

申请日：2011-11-09

申请人： GENENTECH, INC.

发明人： BAKER-GLENN, Charles ,  BURDICK, Daniel John ,  CHAMBERS, Mark ,  CHEN, Huifen ,  ESTRADA, Anthony ,  SWEENEY, Zachary Kevin ,  CHAN, Bryan K.

IPC分类号： C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  A61K31/506 ,  A61P25/16 ,  A61P25/00

摘要： Compounds of the formula I:

or pharmaceutically acceptable salts thereof,
wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.