专利检索 ap:("GLAXO GROUP LIMITED") AND inv:"PAYNE, Jeremy, John, c/o GlaxoSmithKline" 第 1 页

1.

发明授权
17.BETA.-CARBOTHIOATE 17.ALPHA.-ARYLCARBONYLOXYLOXY ANDROSTANE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS 无效
标题翻译： 17.BETA.-CARBOTHIOAT 17.ALPHA.-ARYLKARBONYLOXYLOXY ANDROSTANDERIVATE ALS ANTI-PHLOGISTISCHE MEDIKAMENTE

公开(公告)号：EP1305330B1

公开(公告)日：2008-12-03

申请号：EP01954149.9

申请日：2001-08-03

申请人： GLAXO GROUP LIMITED

发明人： BIGGADIKE, Keith, c/o GlaxoSmithKline , JONES, Paul, c/o GlaxoSmithKline , PAYNE, Jeremy, John, c/o GlaxoSmithKline

IPC分类号： C07J31/00 , A61K31/58 , C07J33/00 , C07J71/00 , C07J3/00 , A61P5/44

CPC分类号： C07J31/006

摘要： There are provided according to the invention compounds of formula (I) wherein R1 represents C1-6 alkyl or C1-6 haloalkyl; R2 represents -C(=O)-aryl or -C(=O)-heteroaryl; R3 represents hydrogen, methyl (which may be in either the α or β configuration) or methylene; R4 and R5 are the same or different and each represents hydrogen or halogen; and ---- represents a single or a double bond; and salts and solvates thereof. There are also provided processes for preparing compounds of formula (I) and use of the compounds in therapy especially in the treatment of inflammatory and allergic conditions.