公开(公告)号：EP2788772A4

公开(公告)日：2015-04-15

申请号：EP12855131

申请日：2012-12-06

申请人： GLAXOSMITHKLINE LLC ,  KINEMED INC ,  LEONARD MICHAEL S

发明人： HELLERSTEIN MARC K ,  EVANS WILLIAM

IPC分类号： G01N33/70

CPC分类号： A61B5/4869 ,  A61B5/107 ,  A61B5/15 ,  A61B5/4519 ,  A61B10/007 ,  G01N30/7233 ,  G01N33/493 ,  G01N33/70 ,  H01J49/0036 ,  H01J49/004

摘要： The present invention is based on the finding that enrichment of D3-creatinine in a urine sample following oral administration of a single defined dose of D3-creatine can be used to calculate total-body creatine pool size and total body skeletal muscle mass in a subject. The invention further encompasses methods for detecting creatinine and D3-creatinine in a single sample. The methods of the invention find use, inter alia, in diagnosing disorders related to skeletal muscle mass, and in screening potential therapeutic agents to determine their effects on muscle mass.