公开(公告)号：EP2567967A3

公开(公告)日：2013-08-21

申请号：EP12180322.5

申请日：2005-04-12

申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  GENVEC, INC.

发明人： Nabel, Gary J ,  Cheng, Cheng ,  Kong, Wing-Pui ,  Gall, Jason G D ,  King, C. Richter

IPC分类号： C07K14/16 ,  C12N15/861 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234

摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.

公开(公告)号：EP2567967A2

公开(公告)日：2013-03-13

申请号：EP12180322.5

申请日：2005-04-12

申请人： GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  GENVEC, INC.

发明人： Nabel, Gary J ,  Cheng, Cheng ,  Kong, Wing-Pui ,  Gall, Jason G D ,  King, C. Richter

IPC分类号： C07K14/16 ,  C12N15/861 ,  A61K39/21

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234

摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.

摘要翻译： 本发明提供了在哺乳动物中诱导针对人类免疫缺陷病毒（HIV）的免疫应答的方法。 该方法包括向该哺乳动物施用包含一种或多种编码两种或更多种不同HIV抗原的腺病毒载体的腺病毒载体组合物，其产生在哺乳动物中诱导针对HIV的免疫应答。 本发明还提供了包含分别编码HIV进化枝A Env蛋白，HIV进化枝B Env蛋白，HIV进化枝C Env蛋白和包含HIV进化枝B Gag蛋白和Pol蛋白的融合蛋白的四种腺病毒载体的腺病毒载体组合物 。