Derivatives of squaric acid with anti-proliferative activity
    2.
    发明公开
    Derivatives of squaric acid with anti-proliferative activity 审中-公开
    促进vonQuadratsäuremit Wirkung gegen扩散

    公开(公告)号:EP2096107A1

    公开(公告)日:2009-09-02

    申请号:EP09161687.0

    申请日:2004-12-23

    申请人: GPC Biotech AG

    CPC分类号: C07D213/74 C07D401/12

    摘要: The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers and isomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable salt thereof. These compounds show anti-proliferative activity, including against tumor cells, and arc useful in the treatment of diseases including cancer.

    摘要翻译: 本发明提供方酸的衍生物,特别是3,4-二氨基 - 环丁-3-烯-1,2-二酮及其互变异构体及其异构体的衍生物,作为单一立体异构体或立体异构体的混合物,或作为药学上 其可接受的盐。 这些化合物显示抗增殖活性,包括抗肿瘤细胞,并且可用于治疗包括癌症在内的疾病。

    Derivatives of squaric acid with anti-proliferative activity
    4.
    发明公开
    Derivatives of squaric acid with anti-proliferative activity 有权
    Quadratsäurederivatemit antiproliferativer Wirkung

    公开(公告)号:EP1674457A1

    公开(公告)日:2006-06-28

    申请号:EP04030696.1

    申请日:2004-12-23

    申请人: GPC Biotech AG

    CPC分类号: C07D213/74 C07D401/12

    摘要: The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers thereof, as a single stereoisomer or a mixture of stereoisomers, or as a pharmaceutically acceptable salt thereof. These compounds show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

    wherein
    R 1 is 3-pyridyl or 4-pyridyl.

    摘要翻译: 本发明提供方酸的衍生物,特别是3,4-二氨基 - 环丁-3-烯-1,2-二酮及其互变异构体的衍生物作为单一立体异构体或立体异构体的混合物或作为药学上可接受的盐 它们。 这些化合物显示抗增殖活性,包括抗肿瘤细胞,并且可用于治疗包括癌症在内的疾病。 其中R 1是3-吡啶基或4-吡啶基。