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公开(公告)号:EP1202624A4
公开(公告)日:2002-12-04
申请号:EP00948975
申请日:2000-07-28
发明人: YEOMAN ALAN M , GRUNEWALD FREDRICK A , HOWARTH JONATHAN N , HARRISON ALAN D , SOOK BRIAN R , KRUPPA THOMAS
IPC分类号: C02F1/50 , A01N25/00 , A01N25/04 , A01N25/08 , A01N25/22 , A01N33/18 , A01N35/08 , A01N43/08 , A01N43/50 , A01N43/64 , A01N43/66 , A01N43/70 , A01N47/48 , A01N59/00 , A01N59/08 , A01N25/30 , A01N43/10 , A01N59/06
CPC分类号: A01N43/70 , A01N25/04 , A01N25/08 , A01N25/22 , A01N35/08 , A01N43/08 , A01N43/66 , A01N47/48 , A01N59/00 , A01N2300/00
摘要: A method of improving the rate of dissolution in water of low solubility compounds by combining a low solubility compound with a rheology additive that is made of platelets or particles which orient together with ionic or hydrogen bonds. The inventive method also may improve the hydrolytic stability of hydrolitically unstable low solubility compounds.
摘要翻译: 提高水解不稳定化合物的水解稳定性的方法,包括将所述化合物与水和流变添加剂,以形成在wässrige悬浮液,其包括1%至80%的所述的水解不稳定的化合物。 所述流变添加剂包含与离子键或氢键一起定向,以形成三维结构血小板或颗粒。