公开(公告)号：EP0643620B1

公开(公告)日：1999-07-21

申请号：EP93906328.5

申请日：1992-10-02

申请人： GS DEVELOPMENT AB

发明人： LANDH, Tomas ,  LARSSONS, Kare

IPC分类号： B01J13/00 ,  B01J13/02 ,  A61K9/50

CPC分类号： A61K9/1274 ,  B01J13/00 ,  B01J13/02 ,  C09K19/02 ,  C09K19/544 ,  C09K2019/528 ,  Y10S514/937 ,  Y10S514/964 ,  Y10S516/90 ,  Y10T428/2982

摘要： Particles, especially colloidal particles, comprising an interior phase of a non-lamellar reversed cubic, intermediate or hexagonal liquid crystalline phase, or a homogeneous L3 phase, and a surface phase of a lamellar crystalline or liquid crystalline phase, or an L3 phase. A method of preparing such particles by creating a local dispersible phase, within the homogeneous phase, preferably by means of a fragmentation agent, and fragmentating the homogeneous phase so as to form said surface phase. Several medical as well as non-medical uses of the particles referred to, e.g. as an antigen-presenting system, as a delivery system for anticancer, antifungal and antimicrobial drugs, and as carriers of nucleic acids or nucleotides.