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    ANTIKÖRPER GEGEN T-ZELLEN ALS THERAPEUTIKUM
    2.
    发明公开
    ANTIKÖRPER GEGEN T-ZELLEN ALS THERAPEUTIKUM 失效
    抗体T细胞治疗剂

    公开(公告)号：EP0802924A1

    公开(公告)日：1997-10-29

    申请号：EP95920061.0

    申请日：1995-05-19

    申请人： GSF - Forschungszentrum für Umwelt und Gesundheit GmbH

    发明人： THIERFELDER, Stefan

    IPC分类号： A61K39 ,  A61K47 ,  A61P35 ,  A61P37 ,  C07K16

    CPC分类号： C07K16/2815 ,  A61K47/6849 ,  C07K16/2812 ,  Y10S530/868

    摘要： The invention relates to antibodies against T-cells as therapeutics. It is the aim of the invention to provide antibodies for clinical therapy to prolong the immunosuppressive antibody effect while preventing the formation of anti-antibodies. This is attained by antibodies consisting of at least two different groups which are administered separately in time and in which at least one antibody from group B is distinguished in the constant parts of the heavy chains of an antibody of group A and in which group A, which is applied once or several times as the first one, has a T-cell eliminating action, while the further group B (which is applied after a time lapse) has a T-cell eliminating and/or T-cell antigen modulating effect.