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    Therapeutic composition of non MHC-restricted T-cells/NK-cells and MHC-restricted cells for the treatment of tumors
    1.
    发明公开
    Therapeutic composition of non MHC-restricted T-cells/NK-cells and MHC-restricted cells for the treatment of tumors 有权
    包含非MHC依赖性T细胞/ NK细胞和MHC依赖性细胞肿瘤的治疗的药物组合物

    公开(公告)号：EP1275400A1

    公开(公告)日：2003-01-15

    申请号：EP02015101.5

    申请日：2002-07-05

    申请人： GSF-Forschungszentrum für Umwelt und Gesundheit GmbH

    发明人： Schendel, Dolores ,  Falk, Christine ,  Noessner, Elfriede ,  Weiss, Elisabeth

    IPC分类号： A61K45/06

    CPC分类号： A61K45/06 ,  A61K35/17

    摘要： This invention is directed to therapeutic compositions containing non-MHC-restricted T-cells/NK-cells in combination with MHC-restricted T-cells and especially to therapeutic compositions, which comprise LAK cells. Furthermore, the present invention is directed to the use of the above combination in the treatment of tumors in humans, which tumors show a missing, low or aberrant expression of MHC class 1a or 1b molecules. By using the aforementioned compositions/combinations it is possible to provide a balanced selective pressure against emergence of tumor cell variants that would otherwise escape immune detection.

    摘要翻译： 本发明涉及含有非MHC限制的T细胞/ NK细胞与MHC限制的T细胞的组合治疗组合物和特别爱的治疗组合物，其包含LAK细胞。 进一步地，本发明涉及在人类中治疗肿瘤，其中肿瘤显示MHC类1a或1b分子的缺失，低或异常表达使用上述组合。 通过使用前述组合物/组合物也可以提供针对肿瘤细胞变体的出现平衡的选择压力也否则逃避免疫检测。