公开(公告)号：EP2344460A1

公开(公告)日：2011-07-20

申请号：EP09782854.5

申请日：2009-09-10

申请人： Galapagos N.V.

发明人： NIQUE, François ,  JAGERSCHMIDT, Catherine ,  BLANQUÉ, Roland ,  LEFRANÇOIS, Jean-Michel ,  PEIXOTO, Christophe ,  DEPREZ, Pierre ,  TRIBALLEAU, Nicolas ,  WIGERINCK, Piet, Tom, Bert, Paul ,  NAMOUR, Florence, Sylvie

IPC分类号： C07D233/60 ,  C07D233/66 ,  A61K31/4166 ,  A61P35/00

CPC分类号： C07D233/60 ,  C07D233/66

摘要： Novel compounds are disclosed that have a Formula represented by the following: wherein X, R
1 , R
2a , R
2b , R
2c , R
3a R
3b , R
4a , R
4b , R
4c , and ml are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non- limiting example, cachexia, osteoporosis, sarcopenia, a decline in libido and/or sexual dysfunction.