公开(公告)号：EP1444346B1

公开(公告)日：2008-03-12

申请号：EP02776950.4

申请日：2002-08-29

申请人： Galapagos N.V.

发明人： ARTS, Gert-Jan ,  LANGEMEIJER, Ellen, Vera ,  PIEST, Ivo ,  VAN ES, Helmuth, Hendrikus, Gerardus ,  MICHIELS, Godefridus, Augustinus, Maria

IPC分类号： C12N15/11 ,  C12N5/10 ,  C12N7/00 ,  A61K31/713

CPC分类号： C12N9/22 ,  A01K2217/05 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/12 ,  C12N2330/30 ,  C12N2330/31 ,  C12N2799/022 ,  C12Q1/6876

摘要： The present invention relates to polynucleotide constructs, methods for their preparation, and preparations for their use in methods that lower the amount of RNA and/or protein production in cells based on the intracellular expression of small interfering polyribonucleic acid molecules.

公开(公告)号：EP1444346B2

公开(公告)日：2015-06-24

申请号：EP02776950.4

申请日：2002-08-29

申请人： Galapagos N.V.

发明人： ARTS, Gert-Jan ,  LANGEMEIJER, Ellen, Vera ,  PIEST, Ivo ,  VAN ES, Helmuth, Hendrikus, Gerardus ,  MICHIELS, Godefridus, Augustinus, Maria

IPC分类号： C12N15/11 ,  C12N5/10 ,  C12N7/00 ,  A61K31/713

CPC分类号： C12N9/22 ,  A01K2217/05 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2320/12 ,  C12N2330/30 ,  C12N2330/31 ,  C12N2799/022 ,  C12Q1/6876