公开(公告)号：EP2414829A1

公开(公告)日：2012-02-08

申请号：EP10712085.9

申请日：2010-04-01

申请人： Galapagos N.V.

发明人： BRYS, Reginald Christophe Xavier ,  NELLES, Luc ,  VANDEGHINSTE, Nick Ernest Rene ,  MILLE-BAKER, Blandine ,  TESSARI, Michela Angela

IPC分类号： G01N33/50

CPC分类号： C12N15/1137 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/5032 ,  G01N33/6887 ,  G01N2333/726 ,  G01N2333/912 ,  G01N2333/9121 ,  G01N2333/96486 ,  G01N2333/96494 ,  G01N2500/04 ,  G01N2500/10 ,  G01N2500/20 ,  G01N2800/105

摘要： The invention relates to the field of medicinal research, cartilage physiology and diseases involving the degeneration of cartilage tissue. More specifically, the invention relates to methods and means for identifying compounds that inhibit catabolic processes in chondrocytes and that decrease the degradation of cartilage and/or ECM. The invention also relates to the compounds that are useful in the treatment of osteoarthritis. The invention also relates to targets, the modulation of which results in a decrease in the degradation of ECM and /or cartilage and decrease inflammation. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by the degradation of ECM and /or cartilage and inflammation.