专利检索 ap:("Gambro, Inc.,") AND inv:"BECK, Werner" 第 1 页

1.

发明公开
SOLUTION AND METHOD TO REDUCE, TREAT AND/OR PREVENT OXIDATIVE STRESS AND CELL ACTIVATION 有权
标题翻译：溶液，其中含有用于减轻，治疗和/或预防氧化应激和细胞活化的N-乙酰基半胱氨酸和葡糖酸，和方法

公开(公告)号：EP2040689A2

公开(公告)日：2009-04-01

申请号：EP07764759.2

申请日：2007-06-21

申请人： Gambro, Inc.,

发明人： DEPPISCH, Reinhold , BECK, Werner , SCHNELL, Andrea , DRIESCHMANNS, Hans-Rainer

IPC分类号： A61K31/191 , A61K31/198 , A61K31/375 , A61K38/38 , A61P39/06 , A61P43/00

CPC分类号： A61K31/191 , A61K9/0019 , A61K31/198 , A61K31/375 , A61K38/063 , A61K38/38 , A61K45/06 , A61K2300/00

摘要： The present invention concerns a solution and methods to reduce, treat and/or prevent oxidative stress and cell activation. According to the invention the solution gives rise to the following concentrations of constituents within a blood flow of 0.1-18 mM N-acetyl-cysteine, optionally of 0.01-0.21 mM vitamin C, optionally of 2-26 mM gluconic acid and optionally of 0.01-5 mM glutathione. According to the invention the methods comprises adding a solution according to the invention in an extracorporeal setting through the membrane by adding the solution to the dialysis fluid, or by infusion of a solution according to the invention, either by bolus injection, continuous injection or a combination thereof.