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1.发明公开Reagents methodsand kits for use in deactivating nucleic acids 有权Reagentien und Verfahren zur Deaktivierung vonNukleinsäuren
公开(公告)号：EP2286845A1
公开(公告)日：2011-02-23
申请号：EP10011173.1
申请日：2005-03-04
发明人： Nelson, Nornan, C. , Browne, Kenneth, A. , Dai, Lizhong , Russell, James , Flipowsky, Mark, E. , Kaminsky, Margarita B. , Kacian, Daniel B.
CPC分类号： C12Q1/68 , A61L2/186 , C11D3/3956 , C12Q1/6848
摘要： A formulation for use in preventing nucleic acids from acting as templates in an amplification reaction when the solution is combined with a nucleic acid deactivating agent, the formulation comprising a corrosion-inhibiting agent, a wetting agent, and a solubilizing agent, wherein each of said agents remains substantially in solution at 22°C, and wherein each agent is present in an amount that when the formulation is combined with an amount of a deactivating agent sufficient for the combined formulation to substantially deactivate nucleic acids, the corrosion-inhibiting agent reduces the corrosive properties of the deactivating agent, the wetting agent improves the dispersion properties of the deactivating agent on a solid surface and/or increases the solubility of the deactivating agent and/or other material that may be present on a solid surface or in a formulation, and the solubilizing agent increases the solubility of at least one of the deactivating agent, the corrosion-inhibiting agent, and the wetting agent.
摘要翻译： 一种用于在将溶液与核酸减活剂组合时用于防止核酸作为扩增反应中的模板的制剂，所述制剂包含腐蚀抑制剂，润湿剂和增溶剂，其中所述 试剂在22℃下基本上保持在溶液中，并且其中每种试剂的存在量是当将制剂与足以使组合制剂基本上使核酸失活的量的减活化剂的量组合时，腐蚀抑制剂减少 钝化剂的腐蚀性质，润湿剂改善钝化剂在固体表面上的分散性能和/或增加可能存在于固体表面或制剂上的失活剂和/或其它材料的溶解度， 并且增溶剂增加至少一种钝化剂，腐蚀抑制剂的溶解度 g剂和润湿剂。
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公开(公告)号：EP2286845B1
公开(公告)日：2016-11-16
申请号：EP10011173.1
申请日：2005-03-04
发明人： Nelson, Nornan, C. , Browne, Kenneth, A. , Dai, Lizhong , Russell, James , Flipowsky, Mark, E. , Kaminsky, Margarita B. , Kacian, Daniel B.
CPC分类号： C12Q1/68 , A61L2/186 , C11D3/3956 , C12Q1/6848
摘要： A formulation for use in preventing nucleic acids from acting as templates in an amplification reaction when the solution is combined with a nucleic acid deactivating agent, the formulation comprising a corrosion-inhibiting agent, a wetting agent, and a solubilizing agent, wherein each of said agents remains substantially in solution at 22°C, and wherein each agent is present in an amount that when the formulation is combined with an amount of a deactivating agent sufficient for the combined formulation to substantially deactivate nucleic acids, the corrosion-inhibiting agent reduces the corrosive properties of the deactivating agent, the wetting agent improves the dispersion properties of the deactivating agent on a solid surface and/or increases the solubility of the deactivating agent and/or other material that may be present on a solid surface or in a formulation, and the solubilizing agent increases the solubility of at least one of the deactivating agent, the corrosion-inhibiting agent, and the wetting agent.
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