公开(公告)号：EP3181147A1

公开(公告)日：2017-06-21

申请号：EP16197439.9

申请日：2007-11-20

申请人： Genentech, Inc.

发明人： GURNEY, Austin, L ,  BALAZS, Mercedesz ,  GHILARDI, Nico ,  HYMOWITZ, Sarah ,  HASS, Philip, E ,  STAROVASNIK, Melissa, A ,  WU, Yan ,  LEE, James, M ,  ARNOTT, David, P ,  OUYANG, Wenjun

IPC分类号： A61K38/20 ,  C07K14/54 ,  C07K16/24

CPC分类号： C07K16/244 ,  A61K38/2073 ,  A61K2039/505 ,  C07K14/54 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  C07K2319/40 ,  G01N2500/10 ,  G01N2800/24 ,  Y02A50/463

摘要： The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17 A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.

摘要翻译： 本发明涉及一种新的天然存在的人细胞因子，其由白介素17和白细胞介素17F的异二聚体组成，在本文中称为白细胞介素17A / F（IL-17A / F）。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，结合本发明多肽的特异性抗体以及用于产生本发明多肽的方法 本发明。 本文进一步提供了用于治疗退行性软骨病症和其他炎性疾病的方法。