公开(公告)号：EP2148858A1

公开(公告)日：2010-02-03

申请号：EP08747109.0

申请日：2008-04-29

申请人： Genentech, Inc.

发明人： FLYGARE, John A. ,  COHEN, Frederick ,  DESHAYES, Kurt ,  KOEHLER, Michael F. T. ,  GAZZARD, Lewis J. ,  WANG, Lan ,  NDUBAKU, Chudi

IPC分类号： C07D209/02 ,  C07D263/06 ,  C07D513/04

CPC分类号： C07D417/14 ,  C07D207/16 ,  C07D519/00

摘要： The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds having the general formula U1 - M - U2 wherein M is a linking group covalently joining R2, R3, R4 or R5 of U1 to an R2, R3, R4 or R5 group of U2; U1 and U2 have the general formula (I) and G, X1, X2, R2, R3, R3', R4, R4' and R5, are as described herein.