公开(公告)号：EP3089980A1

公开(公告)日：2016-11-09

申请号：EP14827387.3

申请日：2014-12-29

申请人： Array Biopharma, Inc. ,  Genentech, Inc.

发明人： BLAKE, James, F. ,  COOK, Adam ,  GAUDINO, John ,  GUNAWARDANA, Indrani, W. ,  HICKEN, Erik, James ,  HUNT, Kevin, W. ,  LYON, Michael ,  METCALF, Andrew, T. ,  MOHR, Peter, J. ,  MORENO, David, A. ,  NEWHOUSE, Brad ,  REN, Li ,  SCHWARZ, Jacob ,  CHEN, Huifen ,  GAZZARD, Lewis ,  SCHMIDT, Jane ,  DO, Steve

IPC分类号： C07D487/04 ,  A61K31/444 ,  A61K31/506 ,  A61P29/00

CPC分类号： C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

摘要翻译： 提供式I化合物或其立体异构体，互变异构体或药学上可接受的盐，其可用于治疗疾病。 公开了使用式I化合物或其立体异构体，互变异构体或药学上可接受的盐在体外，原位和体内诊断，预防或治疗这些疾病或相关病理学病症的方法。

公开(公告)号：EP3089980B1

公开(公告)日：2018-01-31

申请号：EP14827387.3

申请日：2014-12-29

申请人： Array Biopharma, Inc. ,  Genentech, Inc.

发明人： BLAKE, James, F. ,  COOK, Adam ,  GAUDINO, John ,  GUNAWARDANA, Indrani, W. ,  HICKEN, Erik, James ,  HUNT, Kevin, W. ,  LYON, Michael ,  METCALF, Andrew, T. ,  MOHR, Peter, J. ,  MORENO, David, A. ,  NEWHOUSE, Brad ,  REN, Li ,  SCHWARZ, Jacob ,  CHEN, Huifen ,  GAZZARD, Lewis ,  SCHMIDT, Jane ,  DO, Steve

IPC分类号： C07D487/04 ,  A61K31/444 ,  A61K31/506 ,  A61P29/00

CPC分类号： C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D487/04 ,  C07D519/00

摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

公开(公告)号：EP3089788B1

公开(公告)日：2018-10-24

申请号：EP14827985.4

申请日：2014-12-29

申请人： Genentech, Inc. ,  Array Biopharma, Inc.

发明人： BLAKE, James, F. ,  COOK, Adam ,  GUNAWARDANA, Indrani, W. ,  HUNT, Kevin, W. ,  LYON, Michael ,  METCALF, Andrew, T. ,  MOHR, Peter, J. ,  MORENO, David, A. ,  NEWHOUSE, Brad ,  REN, Li ,  TANG, Tony, P. ,  THOMAS, Allen, A. ,  SCHWARZ, Jacob ,  SCHMIDT, Jane ,  GAZZARD, Lewis ,  CHEN, Huifen

IPC分类号： A61P35/00 ,  A61K31/506 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14

CPC分类号： A61K31/506 ,  A61K31/4439 ,  A61K31/444 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

公开(公告)号：EP3089788A1

公开(公告)日：2016-11-09

申请号：EP14827985.4

申请日：2014-12-29

申请人： Genentech, Inc. ,  Array Biopharma, Inc.

发明人： BLAKE, James, F. ,  COOK, Adam ,  GUNAWARDANA, Indrani, W. ,  HUNT, Kevin, W. ,  LYON, Michael ,  METCALF, Andrew, T. ,  MOHR, Peter, J. ,  MORENO, David, A. ,  NEWHOUSE, Brad ,  REN, Li ,  TANG, Tony, P. ,  THOMAS, Allen, A. ,  SCHWARZ, Jacob ,  SCHMIDT, Jane ,  GAZZARD, Lewis ,  CHEN, Huifen

IPC分类号： A61P35/00 ,  A61K31/506 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04 ,  C07D403/14 ,  C07D417/14

CPC分类号： A61K31/506 ,  A61K31/4439 ,  A61K31/444 ,  A61K45/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

摘要翻译： 提供式I化合物或其立体异构体，互变异构体或药学上可接受的盐，其可用于治疗过度增殖性疼痛和炎性疾病。 公开了使用式I化合物或其立体异构体，互变异构体或药学上可接受的盐在体外，原位和体内诊断，预防或治疗哺乳动物细胞中的此类病症或相关病理学病症的方法。