POLYMERASE VARIANTS
    1.
    发明公开
    POLYMERASE VARIANTS 审中-公开

    公开(公告)号:EP3929283A1

    公开(公告)日:2021-12-29

    申请号:EP21164826.6

    申请日:2017-02-27

    IPC分类号: C12N9/12

    摘要: The present disclosure provides variant Pol6 polymerase polypeptides, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental Pol6 polypeptides from which they are derived.