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公开(公告)号：EP2668258A1
公开(公告)日：2013-12-04
申请号：EP12739380.9
申请日：2012-01-10
发明人： CHEN, Roger
IPC分类号： C12M1/38
CPC分类号： B01J19/0046 , B01J2219/00495 , B01J2219/00698 , G05D23/1919 , G05D23/2034 , G05D23/2037
摘要： A system for regulating a temperature of a measurement array is disclosed. The system includes a measurement array including a plurality of sensors, wherein the plurality of sensors are integrated onto an integrated circuit die. The system includes a thermal sensor integrated onto the integrated circuit die, wherein the thermal sensor senses a temperature associated with the plurality of sensors. The system further includes a heat pump coupled to the integrated circuit die, wherein the heat pump is controlled by a feedback control circuit including the thermal sensor.
摘要翻译： 公开了一种用于调节测量阵列的温度的系统。 该系统包括包括多个传感器的测量阵列，其中多个传感器集成在集成电路管芯上。 该系统包括集成在集成电路管芯上的热传感器，其中热传感器感测与多个传感器相关联的温度。 该系统还包括耦合到集成电路管芯的热泵，其中热泵由包括热传感器的反馈控制电路控制。
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公开(公告)号：EP2861768A1
公开(公告)日：2015-04-22
申请号：EP13804403.7
申请日：2013-06-14
CPC分类号： G01N27/44791 , C12Q1/6869 , G01N33/48721 , C12Q2565/631
摘要： The present disclosure provides devices, systems and methods for sequencing nucleic acid molecules. Nucleic acid molecules can be sequenced with a high accuracy (e.g., greater than 97% in a single pass) using a chip comprising an array of independently addressable nanopore sensors at a density of at least about 500 sites per 1 mm. An individual nanopore sensor can include a nanopore in a membrane that is adjacent or in proximity to a sensing electrode.
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公开(公告)号：EP3733874A1
公开(公告)日：2020-11-04
申请号：EP20164391.3
申请日：2013-11-07
IPC分类号： C12Q1/6869 , G01N33/487
摘要： The present invention relates to a method for nucleic acid sequencing, the method comprising: (a) providing a single stranded nucleic acid; (b) providing a plurality of probes; (c) polymerizing the plurality of probes in an order determined by hybridization of the hybridization moieties with the single stranded nucleic acid to be sequenced; (d) cleaving the cleavable groups to provide an expanded thread to be sequenced; (e) threading the expanded thread through a nanopore, wherein the gates prevent the expanded thread from threading through the nanopore in the reverse direction; and (f) detecting, with the aid of the nanopore, the loop structures of the expanded thread in the order determined by hybridization of the hybridization moieties with the single stranded nucleic acid to be sequenced, thereby sequencing the single stranded nucleic acid to be sequenced.
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公开(公告)号：EP2668645B1
公开(公告)日：2020-09-30
申请号：EP11857055.5
申请日：2011-12-12
发明人： CHEN, Roger
IPC分类号： G01N33/487
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公开(公告)号：EP2814983B1
公开(公告)日：2019-04-24
申请号：EP13748712.0
申请日：2013-02-15
发明人： DAVIS, Randall , CHEN, Roger
IPC分类号： C12Q1/6869 , C12N15/11 , G01N27/327 , G01N33/487 , G01N33/543
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公开(公告)号：EP2917372A1
公开(公告)日：2015-09-16
申请号：EP13853114.0
申请日：2013-11-07
CPC分类号： C12Q1/6869 , G01N27/44717 , G01N27/44791 , G01N33/48721 , C12Q2527/113 , C12Q2535/122 , C12Q2563/113 , C12Q2565/631 , C12Q2537/157
摘要： This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a membrane. An individual tagged nucleotide of the tagged nucleotides can contain a tag coupled to a nucleotide, which tag is detectable with the aid of the nanopore. Next, an individual tagged nucleotide of the tagged nucleotides can be incorporated into a growing strand complementary to a single stranded nucleic acid molecule derived from the nucleic acid sample. With the aid of the nanopore, a tag associated with the individual tagged nucleotide can be detected upon incorporation of the individual tagged nucleotide. The tag can be detected with the aid of the nanopore when the tag is released from the nucleotide.
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公开(公告)号：EP2864502A1
公开(公告)日：2015-04-29
申请号：EP13807639.3
申请日：2013-04-08
发明人： JU, Jingyue , DAVIS, Randall , CHEN, Roger
CPC分类号： C12Q1/6869 , G01N33/48721 , C12Q2521/101 , C12Q2521/543 , C12Q2537/157 , C12Q2565/631
摘要： This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule.
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公开(公告)号：EP2814983A1
公开(公告)日：2014-12-24
申请号：EP13748712.0
申请日：2013-02-15
发明人： DAVIS, Randall , CHEN, Roger
CPC分类号： C12Q1/6869 , C12N15/111 , C12N2310/11 , C12N2310/16 , C12N2310/3517 , C12N2320/10 , C12N2320/32 , G01N33/48721 , G01N33/5432 , C12Q2565/607 , C12Q2565/631
摘要： The present disclosure provides biochips and methods for making biochips. A biochip can comprise a nanopore in a membrane (e.g., lipid bilayer) adjacent or in proximity to an electrode. Methods are described for forming the membrane and inserting the nanopore into the membrane. The biochips and methods can be used for nucleic acid (e.g., DNA) sequencing. The present disclosure also describes methods for detecting, sorting, and binning molecules (e.g., proteins) using biochips.
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公开(公告)号：EP2668645A2
公开(公告)日：2013-12-04
申请号：EP11857055.5
申请日：2011-12-12
发明人： CHEN, Roger
IPC分类号： G08C15/06
摘要： A system for communicating information from an array of sensors is disclosed. The system comprises a sensor array that includes a plurality of sensors, wherein each sensor senses a physical property of a material that is in communication with the sensor. The system further comprises signal processing circuitry associated with each sensor that integrates the output of the sensor over time and compares the integrated output to a threshold. The system further comprises a communication network coupled to the signal processing circuitry that outputs information indicating that the integrated output corresponding to a given sensor has reached the threshold.
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公开(公告)号：EP2917372B1
公开(公告)日：2020-04-08
申请号：EP13853114.0
申请日：2013-11-07
IPC分类号： C12Q1/6869 , G01N27/447 , G01N33/487
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