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1.发明公开METHOD FOR PURIFYING LACTONE COMPOUND HAVING UNSATURATED ALKYL GROUP BY EXTRACTION WITH SILVER ION SOLUTION 有权VERFAHREN ZUM REINIGEN VON FK506麻醉精油麻醉师EINERSILBERIONENLÖSUNG
公开(公告)号：EP2353686A1
公开(公告)日：2011-08-10
申请号：EP09814735.8
申请日：2009-08-03
申请人： Genotech Co., Ltd
发明人： KIM, Jae Jong , LIM, Si Kyu , LEE, Mi Ok , LIM, Sang Myoun , LEE, Bo-Mi , KIM, Dong Hwan , LEE, Keum Soon , RYU, Jeoung Hyun
IPC分类号： B01D17/05
CPC分类号： C07D498/18
摘要： The present invention relates to a method for separating and purifying a lactone compound with an unsaturated alkyl group from a lactone compound with a saturated alkyl group which is an analog thereof. More specifically, the present invention relates to a method for effectively separating a lactone compound with an unsaturated alkyl group such as FK506 at high purity by extraction with a silver ion (Ag + ) solution without use of column chromatography.
摘要翻译： 本发明涉及从具有饱和烷基的内酯化合物（其类似物）分离和纯化具有不饱和烷基的内酯化合物的方法。 更具体地说，本发明涉及通过用银离子（Ag +）溶液萃取而不使用柱色谱法，以高纯度有效分离内酯化合物与不饱和烷基如FK506的方法。
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2.发明公开METHOD OF EXTRACTION AND YIELD-UP OF TRICYCLO COMPOUNDS BY ADDING A SOLID ADSORBENT RESIN AS THEIR CARRIER IN FERMENTATION MEDIUM 审中-公开提取和增加三环效率的方法，通过增加FIXED吸附作为其载体发酵培养基
公开(公告)号：EP2185714A1
公开(公告)日：2010-05-19
申请号：EP08753317.0
申请日：2008-05-06
申请人： Genotech Co., Ltd
发明人： KIM, Jae Jong , LIM, Si Kyu , LEE, Mi Ok , LIM, Sang Myoun , LEE, Bo-mi , KIM, Dong Hwan , RYU, Jeoung Hyun , LEE, Keum Soon
IPC分类号： C12P17/18
CPC分类号： C12P17/18 , C12P17/188
摘要： The present invention relates to a fermentation and purification method of tricyclo compounds, especially FK506 and/or FK520, in detail, relates to a purification method by adding a hydrophobic adsorbent resin as their carrier in a culturing step of FK506 and/or FK520 FK506 producing bacteria.
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