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公开(公告)号：EP2049014A2
公开(公告)日：2009-04-22
申请号：EP07810553.3
申请日：2007-07-16
申请人： GENZYME CORPORATION
IPC分类号： A61B5/055
CPC分类号： C07C211/14 , A61K31/785 , A61K47/59 , A61K47/595
摘要： Ion binding compounds and compositions may include compounds, polymers and compositions that include amine moieties. Ion binding polymers may be crosslinked amine polymers and may be used to remove ions, such as phosphate ions, from the gastrointestinal tract of animals, such as humans. Such compounds, polymers and compositions may be used therapeutically to treat a variety of medical conditions, such as hyperphosphatemia.
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公开(公告)号：EP2043627A2
公开(公告)日：2009-04-08
申请号：EP07796408.8
申请日：2007-06-25
申请人： GENZYME CORPORATION
IPC分类号： A61K31/295 , A61K33/26 , A61K9/14
CPC分类号： A61K33/26 , A61K9/145 , A61K9/146 , A61K31/295 , A61K31/785 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition comprises a pharmaceutically acceptable ferrous iron compound; an amine polymer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. Alternatively, a pharmaceutica composition comprises a pharmaceutically acceptable ferrous iron compound and pharmaceutically acceptable carrier, wherein the ferrous iron compound is selecte from the group consisting of iron(II) acetate, iron(II) citrate, iron(II) ascorbate, iron(II) oxalate, iron(II) oxide, iron(II) carbonate, iron(II) carbonate saccharated, iron(II) formate, iron(II) sulfate, iron(II) chloride, iron(II) acetylacetonate and combinations thereof. A method of treating a subject with hyperphosphatemia comprises administering to the subject an effective amount of a pharmaceutical composition as described above.
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公开(公告)号：EP1485391B1
公开(公告)日：2006-08-23
申请号：EP03714264.3
申请日：2003-03-19
申请人： GENZYME CORPORATION
CPC分类号： C07F9/65502 , C07F9/3821 , C07F9/4012 , C07F9/5537 , C08F8/40 , C08F30/02 , Y02P20/55
摘要： Disclosed is a phosphate transport inhibiting compound represented by Structural Formula (I). R1 and R2 are independently -H, an electron withdrawing group or a C1-C10 alkyl group. Y is a covalent bond, a substituted methylene group, an unsubstituted methylene group or -CR1R2P(O)(OH)-. R3 is a hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a substituted hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a heteroaryl group, a substituted heteroaryl group or a phenyl group substituted with one or more groups selected from -C1, -Br, -F, -CN, -NO2, -ORa, -N(Ra)2, -COORa, -CON(Ra)2, -CORa, -S(O)Ra, -S(O)2Ra, -S(O)2N(Ra)2, -NRaS(O)2Ra, -NRaCORa, a halogenated lower alkyl group, an aryl group, a substituted aryl group, or a halogenated alkoxy group. Each Ra is independently -H, lower alkyl, substituted lower alkyl, aryl or substituted aryl. Each Rb is independently -H, a lower alkyl group, or a phosphate protecting group.
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公开(公告)号：EP1945196A2
公开(公告)日：2008-07-23
申请号：EP06837106.1
申请日：2006-11-07
申请人： GENZYME CORPORATION
IPC分类号： A61K31/132 , A61K33/06
CPC分类号： A61K31/785 , A61K31/132 , A61K33/06 , A61K2300/00
摘要： A pharmaceutical composition comprising an aliphatic amine polymer or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable magnesium compound comprising a magnesium ion is disclosed. A method of treating hyperphosphatemia in a patient is also disclosed. The method comprises the step of administering to the subject an effective amount of the disclosed pharmaceutical composition.
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公开(公告)号：EP1485391A2
公开(公告)日：2004-12-15
申请号：EP03714264.3
申请日：2003-03-19
申请人： GENZYME CORPORATION
CPC分类号： C07F9/65502 , C07F9/3821 , C07F9/4012 , C07F9/5537 , C08F8/40 , C08F30/02 , Y02P20/55
摘要： Disclosed is a phosphate transport inhibiting compound represented by Structural Formula (I). R1 and R2 are independently -H, an electron withdrawing group or a C1-C10 alkyl group. Y is a covalent bond, a substituted methylene group, an unsubstituted methylene group or -CR1R2P(O)(OH)-. R3 is a hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a substituted hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a heteroaryl group, a substituted heteroaryl group or a phenyl group substituted with one or more groups selected from -C1, -Br, -F, -CN, -NO2, -ORa, -N(Ra)2, -COORa, -CON(Ra)2, -CORa, -S(O)Ra, -S(O)2Ra, -S(O)2N(Ra)2, -NRaS(O)2Ra, -NRaCORa, a halogenated lower alkyl group, an aryl group, a substituted aryl group, or a halogenated alkoxy group. Each Ra is independently -H, lower alkyl, substituted lower alkyl, aryl or substituted aryl. Each Rb is independently -H, a lower alkyl group, or a phosphate protecting group.
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公开(公告)号：EP2152277A1
公开(公告)日：2010-02-17
申请号：EP08743263.9
申请日：2008-04-25
申请人： Genzyme Corporation
发明人： DHAL, Pradeep, K. , HOLMES-FARLEY, Stephen, Randall , HUVAL, Chad, C. , POLOMOSCANIK, Steven, C.
IPC分类号： A61K31/74
CPC分类号： A61K31/785 , A61K31/131 , A61K31/74 , A61K2300/00
摘要： Amide compounds, amide polymers and compositions including amide compounds and amide polymers may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, the amide polymers may be amido-amine dendrimers that may be formed via a series of iterative reactions.
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公开(公告)号：EP2114376A1
公开(公告)日：2009-11-11
申请号：EP08725806.7
申请日：2008-02-20
申请人： Genzyme Corporation
发明人： POLOMOSCANIK, Steven, C. , HOLMES-FARLEY, Stephen, Randall , DHAL, Pradeep, K. , HUVAL, Chad, C.
IPC分类号： A61K9/14 , A61K31/785 , A61K31/795
CPC分类号： A61K31/785 , A61K31/795 , C08G73/0206
摘要： A pharmaceutical composition for treating hyperphosphatemia can include polymers derived from multi-amine monomers and multifunctional monomers, where the multifunctional monomer includes more than one electrophilic group.
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公开(公告)号：EP1951266A2
公开(公告)日：2008-08-06
申请号：EP06802428.0
申请日：2006-08-25
申请人： GENZYME CORPORATION
IPC分类号： A61K31/785 , A61K31/787 , C08F226/02 , C08F226/04 , C08F226/06
CPC分类号： A61K31/785 , A61K31/77 , A61K31/787 , C08F226/02 , C08F226/04 , C08F226/06
摘要： Polymers and compositions utilizing such polymers are disclosed for treating hyperphosphatemia and other illnesses associated with elevated serum phosphate levels. Phosphate binding polymers, or a pharmaceutically acceptable salt of the polymers, comprise pendent groups extending from a backbone of the polymer. Each pendent group comprises at least two nitrogen-bearing functional groups which bind phosphate. Variations of such polymer and compositions are disclosed.
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公开(公告)号：EP2131820A1
公开(公告)日：2009-12-16
申请号：EP08726435.4
申请日：2008-03-05
申请人： Genzyme Corporation
发明人： DHAL, Pradeep, K. , HOLMES-FARLEY, Stephen, Randall , HUVAL, Chad, C. , POLOMOSCANIK, Steven, C.
IPC分类号： A61K9/48
CPC分类号： C08G75/20 , C08G65/24 , C08G73/0253
摘要： Sulfone-containing copolymers and copolymer networks and compositions including sulfone-containing copolymers and copolymer networks may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, sulfone-containing copolymers and copolymer networks may be derived from a multi- amine monomer and a multifunctional sulfonyl-containing monomer comprising two or more amine-reactive groups.
摘要翻译： 含砜共聚物和共聚物网络以及包含含砜共聚物和共聚物网络的组合物可用于结合目标离子，例如动物胃肠道中的含磷化合物。 在一些情况下，含砜共聚物和共聚物网络可以衍生自多胺单体和包含两个或更多个胺反应性基团的多官能磺酰基单体。
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公开(公告)号：EP2068819A2
公开(公告)日：2009-06-17
申请号：EP07837624.1
申请日：2007-08-31
申请人： GENZYME CORPORATION
发明人： COOPER, Christopher , DHAL, Pradeep, K. , GIMI, Rayomand, H. , HARRIS, David, J. , HOLMES-FARLEY, Stephen, Randall , HUVAL, Chad, C. , LEE, Edward
IPC分类号： A61K8/72
CPC分类号： C07C217/08 , A61K31/785
摘要： Amine compounds, amine polymers, crosslinked amine polymers and pharmaceutical compositions comprising the same may include polyhydroxy-containing cores that may be substituted with amine groups and may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.
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