公开(公告)号：EP2078204A2

公开(公告)日：2009-07-15

申请号：EP07852996.3

申请日：2007-10-29

申请人： George Mason Intellectual Properties, Inc. ,  Istituto Superiore di Sanità

发明人： PETRICOIN, III Emanuel ,  LIOTTA, Lance A. ,  PIEROBON, Mariaelena ,  CALVERT, Valerie

IPC分类号： G01N33/574 ,  G01N33/68

CPC分类号： G01N33/57419 ,  C12Q1/485 ,  G01N2333/90245

摘要： This invention relates, e.g., to a method for predicting the prognosis, the likelihood of metastasis in, or the desirability of administering an aggressive therapy to, a subject with colorectal cancer, comprising determining, in a sample from the subject, the level of phosphorylation compared to a positive and/or negative reference standard, of one or more of: (a) AKT (S473); (b) BAD (S l 12); (c) cABL (T735); (d) ERK (T42/44); (e) MARCKS (S 152- 156); (0 p38MAPK (T l 80- 182): (g) STAT l (Y701 ); (h) PTEN (S380); (i) EGFR (Y992); (j) PAK 1 /2 (S l 19/204); or (k) PKC zeta/lambda (T410-403); or the total amount of (1) COX-2 protein; wherein if the level of phosphorylation of one or more of a-i or the total amount of COX-2 protein (1) is elevated compared to the negative reference standard, and/or i f the level of phosphorylation of j or k is decreased compared to the positive reference standard, the subject has poor prognosis, is likely to undergo metastasis, and/or is a good candidate for aggressive therapy. Also described are methods for treating subjects likely to develop metastatic colorectal carcinoma, and pharmaceutical compositions and kits for implementing methods of the invention.

公开(公告)号：EP2089055A2

公开(公告)日：2009-08-19

申请号：EP07867299.5

申请日：2007-10-31

申请人： George Mason Intellectual Properties, Inc.

发明人： PETRICOIN, Emanuel ,  PIEROBON, Mariaelena ,  CALVERT, Valerie ,  LIOTTA, Lance

IPC分类号： A61K39/395

CPC分类号： G01N33/57419 ,  A61K31/506 ,  A61K39/39558 ,  C07K16/22 ,  G01N33/57438 ,  G01N2800/52

摘要： Methods are provided for treating cancer metastasis by administering a therapeutic composition targeting a kinase substrate cascade.