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1.发明公开BENZOTHIAZOL- 6 -YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION 有权苯并噻唑-6-基乙酸衍生物及其用于HIV感染的治疗
公开(公告)号：EP2788336A1
公开(公告)日：2014-10-15
申请号：EP13719355.3
申请日：2013-04-19
发明人： BABAOGLU, Kerim , BRIZGYS, Gediminas , CHA, Jake , CHEN, Xiaowu , GUO, Hongyan , HALCOMB, Randall, L. , HAN, Xiaochun , HUANG, Richard , LIU, Hongtao , MCFADDEN, Ryan , MITCHELL, Michael, L. , QI, Yingmei , ROETHLE, Paul, A. , XU, Lianhong , YANG, Hong
IPC分类号： C07D277/66 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K31/428 , A61P31/18
CPC分类号： C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
摘要： Compounds disclosed herein including compounds of formula (I') and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.
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2.发明授权DERIVATIVES OF PURINE OR DEAZAPURINE USEFUL FOR THE TREATMENT OF (INTER ALIA) VIRAL INFECTIONS 有权用于治疗（间）疱疹病毒感染的嘌呤或脱氮嘌呤衍生物
公开(公告)号：EP2491035B1
公开(公告)日：2017-08-30
申请号：EP10771608.6
申请日：2010-10-15
IPC分类号： C07D473/16 , C07D473/18 , C07D473/24 , A61K31/522 , A61P31/12 , C07D473/34
CPC分类号： A61K31/437 , A61K31/522 , A61K31/5377 , C07D471/04 , C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34
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3.发明授权BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION 有权苯并噻唑-6-基乙酸衍生物及其用于HIV感染的治疗
公开(公告)号：EP2788336B1
公开(公告)日：2016-03-02
申请号：EP13719355.3
申请日：2013-04-19
发明人： BABAOGLU, Kerim , BRIZGYS, Gediminas , CHA, Jake , CHEN, Xiaowu , GUO, Hongyan , HALCOMB, Randall, L. , HAN, Xiaochun , HUANG, Richard , LIU, Hongtao , MCFADDEN, Ryan , MITCHELL, Michael, L. , QI, Yingmei , ROETHLE, Paul, A. , XU, Lianhong , YANG, Hong
IPC分类号： C07D277/66 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K31/428 , A61P31/18 , A61K45/06 , A61K31/444
CPC分类号： C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
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公开(公告)号：EP2364314B1
公开(公告)日：2014-03-12
申请号：EP09775438.6
申请日：2009-12-07
发明人： DESAI, Manoj, C. , HALCOMB, Randall, L. , HRVATIN, Paul , HUI, Hon Chung , MC FADDEN, Ryan , ROETHLE, Paul, A. , YANG, Hong
IPC分类号： C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04 , A61K31/519 , A61P31/12 , A61P35/00
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
摘要： Provided are intermediates for the production of modulators of toll-like receptors with the following structures:
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5.发明公开DERIVATIVES OF PURINE OR DEAZAPURINE USEFUL FOR THE TREATMENT OF (INTER ALIA) VIRAL INFECTIONS 有权嘌呤或脱氮嘌呤学报（含）的病毒感染的治疗合适的衍生物
公开(公告)号：EP2491035A1
公开(公告)日：2012-08-29
申请号：EP10771608.6
申请日：2010-10-15
IPC分类号： C07D473/16 , C07D473/18 , C07D473/24 , A61K31/522 , A61P31/12 , C07D473/34
CPC分类号： A61K31/437 , A61K31/522 , A61K31/5377 , C07D471/04 , C07D473/16 , C07D473/18 , C07D473/24 , C07D473/34
摘要： The present application includes novel modulators of TLRs, compositions containing such compounds, therapeutic methods that include the administration of such compounds.
摘要翻译： 本申请包括TLR的新颖调节剂，COMPOSITIONS CONTAINING测试的化合物，治疗方法确实包括测试化合物的给药。
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公开(公告)号：EP2364314A1
公开(公告)日：2011-09-14
申请号：EP09775438.6
申请日：2009-12-07
发明人： DESAI, Manoj, C. , HALCOMB, Randall, L. , HRVATIN, Paul , HUI, Hon Chung , MC FADDEN, Ryan , ROETHLE, Paul, A. , YANG, Hong
IPC分类号： C07D475/06 , C07D475/08 , C07D475/12 , C07D487/04 , A61K31/519 , A61P31/12 , A61P35/00
CPC分类号： A61K31/519 , A61K31/527 , A61K31/5377 , A61K31/551 , A61K31/573 , A61K31/683 , A61K31/7056 , A61K31/7072 , A61K31/708 , A61K38/16 , A61K38/21 , A61K38/212 , A61K45/06 , C07D403/12 , C07D475/06 , C07D475/08 , C07D475/10 , C07D475/12 , C07D487/04 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/391 , Y02A50/393 , Y02A50/395
摘要： Provided are intermediates for the production of modulators of toll-like receptors with the following structures:
摘要翻译： 提供用于生产具有以下结构的toll样受体调节剂的中间体：
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公开(公告)号：EP2477987B1
公开(公告)日：2018-01-10
申请号：EP10760831.7
申请日：2010-09-10
IPC分类号： C07D471/04 , A61P31/14 , A61K31/4985
CPC分类号： C07D471/04
摘要： The present invention relates to novel dihydropyrido[4,3 -b]pyrazin-3(4H)-ones of the general formula: useful as modulators of toll-like receptors, and to pharmaceutical compositions containing them.
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8.发明公开BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION 有权苯并噻唑-6-基 - 乙酸衍生物及其用于HIV感染的治疗
公开(公告)号：EP3070081A1
公开(公告)日：2016-09-21
申请号：EP15202564.9
申请日：2013-04-19
发明人： BABAOGLU, Kerim , BRIZGYS, Gediminas , CHA, Jake , CHEN, Xiaowu , GUO, Hongyan , HALCOMB, Randall, L. , HAN, Xiaochun , HUANG, Richard , LIU, Hongtao , MCFADDEN, Ryan , MITCHELL, Michael, L. , QI, Yingmei , ROETHLE, Paul, A. , XU, Lianhong , YANG, Hong
IPC分类号： C07D277/66 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K31/428 , A61P31/18
CPC分类号： C07D277/82 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/4741 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K31/553 , A61K45/06 , C07D277/66 , C07D277/68 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/06 , C07D498/04 , A61K2300/00
摘要： Compounds disclosed herein including compounds of formula I':
and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.摘要翻译： 化合物光盘包括I“式的化合物游离缺失：及其盐中提供它们。 药物组合物包含化合物在游离缺失盘，用于制备化合物游离缺失光盘中，用于制备在使用中提供了这样的化合物游离缺失盘治疗HIV感染和治疗方法的化合物游离缺失光盘的有用中间体的处理。
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公开(公告)号：EP2477987A1
公开(公告)日：2012-07-25
申请号：EP10760831.7
申请日：2010-09-10
IPC分类号： C07D471/04 , A61P31/14 , A61K31/4985
CPC分类号： C07D471/04
摘要： The present invention relates to novel dihydropyrido[4,3 -b]pyrazin-3(4H)-ones of the general formula: useful as modulators of toll-like receptors, and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及通用的新型二氢吡啶并[4,3-b]吡嗪-3（4H） - 酮，其可用作toll样受体的调节剂，以及含有它们的药物组合物。
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