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公开(公告)号：EP2421850A1
公开(公告)日：2012-02-29
申请号：EP10715239.9
申请日：2010-04-23
申请人： Glaxo Group Limited
发明人： AMANTINI, David , FERRONI, Francesco , GIANOTTI, Massimo , PAVONE, Francesca , DI FABIO, Romano
IPC分类号： C07D401/12 , C07D403/14 , C07D413/14 , C07D417/14 , A61K31/44 , A61K31/501 , A61K31/506 , A61P3/04 , A61P25/22 , A61P25/24 , A61P25/30
CPC分类号： C07D401/12 , C07D403/14 , C07D413/14 , C07D417/14
摘要： This invention relates to 3-azabicyclo[4.1.0] heptane derivatives (I) and their use as orexin receptor antagonists.
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2.发明公开N-{[(IR,4S,6R-3-(2-PYRIDINYLCARBONYL)-3-AZABICYCLO [4.1.0]HEPT-4-YL]METHYL}-2-HETEROARYLAMINE DERIVATIVES AND USES THEREOF 审中-公开N - {[（1R，4S，6R）-3-（2-吡啶基羰基）-3-氮杂双环[4.1.0]庚-4-基]甲基} -2- HETEROARYLAMINDERIVATE及其应用
公开(公告)号：EP2370427A1
公开(公告)日：2011-10-05
申请号：EP09760530.7
申请日：2009-11-30
申请人： Glaxo Group Limited
发明人： ALVARO, Giuseppe , AMANTINI, David , CASTIGLIONI, Emiliano , DI FABIO, Romano , PAVONE, Francesca
IPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/55 , A61P25/22 , A61P25/24 , A61P3/04
CPC分类号： C07D401/06 , C07D401/14
摘要： This invention relates to
N -{[(1
S ,4
S ,6
S )-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-heteroarylamine derivatives and their use as pharmaceuticals.-
公开(公告)号：EP2358713A1
公开(公告)日：2011-08-24
申请号：EP08875373.6
申请日：2008-11-26
申请人： Glaxo Group Limited
IPC分类号： C07D487/04 , A61K31/5025 , A61P3/04 , A61P3/10 , A61P25/00 , A61P25/22 , A61P25/24
CPC分类号： C07D487/04
摘要： This invention, relates to imidazopyridazine substituted piperidine derivatives (I) and their use as orexin antagonists.
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4.发明授权QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS 有权第四纪ALPHAAMINOCARBONSÄUREAMIDDERIVATE为电压依赖性钠通道的调节剂
公开(公告)号：EP1934176B1
公开(公告)日：2012-02-01
申请号：EP06806111.8
申请日：2006-10-06
申请人： GLAXO GROUP LIMITED
IPC分类号： C07D207/16 , C07D487/10 , C07D471/10 , A61K31/40 , A61K31/407 , A61K31/435 , A61P23/00 , A61P29/00 , A61P25/08
CPC分类号： C07D207/16 , C07D471/10 , C07D487/10
摘要： The invention relates to quaternary α-aminocarboxyamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, X, q and n are as defined in claim 1, for treating diseases and conditions mediated by modulation of voltage-gated sodium channels.
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5.发明公开IMIDAZO [1, 2-C]PYRIMIDIN-2-YLMETHYLPIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS 审中-公开咪唑并[1,2-C]吡啶二酮-2-甲基乙基哌啶盐酸盐
公开(公告)号：EP2176265A1
公开(公告)日：2010-04-21
申请号：EP08774575.8
申请日：2008-07-01
申请人： Glaxo Group Limited
IPC分类号： C07D487/04 , A61K31/519 , A61P3/04 , A61P3/10
CPC分类号： C07D487/04
摘要： This invention relates to imidazo[1,2-c]pyrimidin-2-ylmethyl substituted piperidine derivatives and their use as pharmaceuticals.
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6.发明公开N-{[(IR,4S,6R-3-(2-PYRIDINYLCARBONYL)-3-AZABICYCLO [4.1.0]HEPT-4-YL]METHYL}-2-HETEROARYLAMINE DERIVATIVES AND USES THEREOF 审中-公开N - {[（1R，4S，6R-3-（2-吡啶基羰基）-3-氮杂环辛[4.1.0]庚基-4-
公开(公告)号：EP2370426A1
公开(公告)日：2011-10-05
申请号：EP09759961.7
申请日：2009-11-30
申请人： Glaxo Group Limited
发明人： ALVARO, Giuseppe , AMANTINI, David , CASTIGLIONI, Emiliano , DI FABIO, Romano , PAVONE, Francesca
IPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/55 , A61P25/22 , A61P25/24 , A61P3/04
CPC分类号： C07D401/14
摘要： This invention relates to
N -{[(1
R ,4
S ,6
R )-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-heteroarylamine derivatives and their use as pharmaceuticals.摘要翻译： 本发明涉及N - {[（1R，4S，6R）-3-（2-吡啶基羰基）-3-氮杂双环[4.1.0]庚-4-基]甲基} -2-杂芳基胺衍生物和它们的 用作药物。
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公开(公告)号：EP2358711A1
公开(公告)日：2011-08-24
申请号：EP08875371.0
申请日：2008-11-26
申请人： Glaxo Group Limited
IPC分类号： C07D487/04 , A61K31/4985 , A61P3/00 , A61P25/00
CPC分类号： C07D487/04
摘要： This invention relates to imidazopyrimidine substituted piperidine derivatives of formula (I) and their use as orexin receptor antagonists useful in the treatment of sleep disorders, mood disorders and anxiety related disorders.
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公开(公告)号：EP2176258A1
公开(公告)日：2010-04-21
申请号：EP08785891.6
申请日：2008-07-01
申请人： Glaxo Group Limited
IPC分类号： C07D471/04 , A61K31/437 , A61P3/00 , A61P7/00 , A61P25/00
CPC分类号： C07D471/04
摘要： This invention relates to imidazo[1,2-alpha]pyridin-2-ylmethyl substituted piperidine derivatives of formula (I) and their use as pharmaceuticals, in the treatment of obesity and diabetes.
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公开(公告)号：EP2379550A1
公开(公告)日：2011-10-26
申请号：EP09795991.0
申请日：2009-12-21
申请人： Glaxo Group Limited
发明人： ALVARO, Giuseppe , AMANTINI, David
IPC分类号： C07D471/04 , A61K31/4439 , A61P25/00
CPC分类号： C07D471/04
摘要： This invention relates to imidazopyridylmethylene substituted piperidine derivatives orexin antagonists and their use as pharmaceuticals.
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公开(公告)号：EP2358712A1
公开(公告)日：2011-08-24
申请号：EP08875372.8
申请日：2008-11-26
申请人： Glaxo Group Limited
IPC分类号： C07D487/04 , A61K31/519 , A61P3/00 , A61P25/00
CPC分类号： C07D487/04
摘要： This invention relates to imidazopyrimidine substituted piperidine derivatives of formula (I) and their use as orexin receptor antagonists useful in the treatment of sleep disorders, mood disorders and anxiety related disorders.
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